Results 51 to 60 of about 776,443 (293)

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation [PDF]

Journal of Biological Chemistry, 2018
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they often occur in tandem, and tools that selectively increase oxidant production without impairing mitochondrial respiration have
Daniel J. Fazakerley, Annabel Y. Minard, James R. Krycer, Kristen C. Thomas, Jacqueline Stöckli, Dylan. J. Harney, James G. Burchfield, Ghassan J. Maghzal, Stuart T. Caldwell, Richard C. Hartley, Roland Stocker, Michael P. Murphy, David E. James   +12 more
openaire   +4 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Superior oxidation resistance in air during hot stamping of a coating-free press-hardened steel achieved by pre-oxidation

Journal of Materials Research and Technology
While coating-free press-hardened steel (CF-PHS) can prevent high-temperature oxidation during hot stamping, it requires high-purity nitrogen protection, which increases the operation cost.
Zhao Li, Lingyu Wang, Zhou Wang, Jianfeng Wang, Wei Xu   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Oxidation Behavior of a Pd_(43)Cu_(27)Ni_(10)P_(20) Bulk Metallic Glass and Foam in Dry Air [PDF]

, 2010
The oxidation behavior of both Pd_(43)Cu_(27)Ni_(10)P_(20) bulk metallic glass (Pd4-BMG) and its amorphous foam containing 45 pct porosity (Pd4-AF) was investigated over the temperature range of 343 K (70 °C) to 623 K (350 °C) in dry air.
Barnard, B., Demetriou, M. D., Johnson, W. L., Kai, W., Liaw, P. K., Ren, I. F.   +5 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Oxidation resistant, thoria-dispersed nickel-chromium-aluminum alloy [PDF]

, 1973
Modified thoria-dispersed nickel-chromium alloy has been developed that exhibits greatly improved resistance to high-temperature oxidation. Additions of aluminum have been made to change nature of protective oxide scale entirely and to essentially ...
Baranow, S., Klingler, L. J.
core   +1 more source

Oxidation resistant tungsten carbide hardmetals [PDF]

International Journal of Refractory Metals and Hard Materials, 2017
Abstract We present a new method for retarding the oxidation rate of hardmetals. By diffusion impregnating a WC-FeCr hardmetal with silicon, we manufacture two-layered silicide coatings consisting of an FeSi x outer crust and WSi 2 beneath. The structure results from a preferential reaction between silicon and the metallic binder. The FeSi x outer
Humphry-Baker, S, Lee, WE, Peng, K
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Properties of Type SiMo Ductile Irons at High Temperatures [PDF]

Archives of Metallurgy and Materials, 2018
Ductile irons of the type of Si-Mo are characterized by increased resistance to long-term influence of high temperatures and cyclic temperature changes.
J. Roučka, E. Abramová, V. Kaňa
doaj   +1 more source