Results 51 to 60 of about 6,998,127 (315)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Ultra-high temperature ceramics modified carbon/carbon composites

Cailiao gongcheng, 2021
Carbon/Carbon(C/C) composites are widely used in aerospace industry due to their diverse advantages such as low density, reliable thermal shock resistance and excellent mechanical properties at elevated temperatures.
XIE Qi-ying, ZHANG Yi, ZHU Yang, CUI Hong   +3 more
doaj   +1 more source

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation [PDF]

Journal of Biological Chemistry, 2018
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they often occur in tandem, and tools that selectively increase oxidant production without impairing mitochondrial respiration have
Daniel J. Fazakerley, Annabel Y. Minard, James R. Krycer, Kristen C. Thomas, Jacqueline Stöckli, Dylan. J. Harney, James G. Burchfield, Ghassan J. Maghzal, Stuart T. Caldwell, Richard C. Hartley, Roland Stocker, Michael P. Murphy, David E. James   +12 more
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Superior oxidation resistance in air during hot stamping of a coating-free press-hardened steel achieved by pre-oxidation

Journal of Materials Research and Technology
While coating-free press-hardened steel (CF-PHS) can prevent high-temperature oxidation during hot stamping, it requires high-purity nitrogen protection, which increases the operation cost.
Zhao Li, Lingyu Wang, Zhou Wang, Jianfeng Wang, Wei Xu   +4 more
doaj   +1 more source

An oxidation-resisitant measurement apparatus [PDF]

Metrology and Measurement Systems, 2019
On the basis of induction heating, radiation heating and liquid nitrogen refrigeration, high-temperature, medium-temperature, normal-temperature and low-temperature heating/refrigeration furnaces were designed, respectively.
Dong-Yang An, Jing-Min Dai, Peng Xiao
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Oxidation resistant tungsten carbide hardmetals [PDF]

International Journal of Refractory Metals and Hard Materials, 2017
Abstract We present a new method for retarding the oxidation rate of hardmetals. By diffusion impregnating a WC-FeCr hardmetal with silicon, we manufacture two-layered silicide coatings consisting of an FeSi x outer crust and WSi 2 beneath. The structure results from a preferential reaction between silicon and the metallic binder. The FeSi x outer
Humphry-Baker, S, Lee, WE, Peng, K
openaire   +3 more sources