Results 121 to 130 of about 558,651 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Using Collective Knowledge to Assign Oxidation States

, 2020
Knowledge of the oxidation state of a metal centre in a material is essential to understand its properties. Chemists have developed several theories to predict the oxidation state on the basis of the chemical formula.
Daniele, Ongari, Kevin Maik, Jablonka, Seyed Mohamad, Moosavi, Berend, Smit   +3 more
core   +1 more source

Promotion of the excited electron transfer over Ni- and Co -sulfide co-doped g-C3N4 photocatalyst (g-C3N4/NixCo1−xS2) for hydrogen Production under visible light irradiation

Scientific Reports, 2017
A Ni- and Co- sulfide co-doped g-C3N4 photocatalyst (g-C3N4/NixCo1−xS2) was prepared by hydrothermal method and this photocatalyst, namely, g-C3N4/NixCo1−xS2 shown excellent photocatalytic properties due to the special structure of Ni-Co-S with boundary ...
Kai Fan, Zhiliang Jin, Hao Yang, Duanduan Liu, Hongyan Hu, Yingpu Bi   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Cycloaddition of Phosphaalkynes to High-Oxidation-State Metal Alkylidenes:  Synthesis and Characterization of a Unique Phosphametallacyclobutene via an Alkoxide Ligand Shift

, 2016
The phosphametallacycle 3, [ArN][RO]MoC(t-Bu)P(OR)C(H)(t-Bu) (Ar = 2,6-(i-Pr)2-C6H3, R = CMe(CF3)2), is formed from the cycloaddition of tert-butylphosphaacetylene to the high-oxidation-state molybdenum alkylidene [ArN][RO]2MoC(H)(t-Bu), accompanied by
Douglas A. Loy (1396201), Mark D. McClain (3082281), Randall S. Saunders (3082284), Joseph W. Ziller (1340067), David R. Wheeler (1634365), Gregory M. Jamison (2669554)   +5 more
core   +1 more source

Ni²⁺ and Cd²⁺ Biosorption Capacity and Redox-Mediated Toxicity Reduction in Bacterial Strains from Highly Contaminated Soils of Uzbekistan

Microorganisms
In this study, Ni2+ and Cd2+ resistant Pseudomonas aeruginosa 18, Enterobacter ludwigii 11Uz, and Enterobacter cloacae Uz_5 strains were isolated from soils contaminated with heavy metals in the Samarkand and Kashkadarya regions (Uzbekistan), and tested ...
Aziza Usmonkulova, Eligio Malusa, Gulchekhra Kadirova, Ilkhom Khalilov, Loredana Canfora, Liliya Abdulmyanova   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise [PDF]

, 2007
Purpose: To determine the impact of carbohydrate (CHO)ingestion on the regulation of fat oxidation following glycogen lowering exercise. Methods: Six males (age 23.4 2 1.7y, vo2peak 58.0 2 2.1 ml.kg-'.min-') participated in the study.
Sarsfield, Fiona
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Catalysis of Synergistic Reactions by Host–Guest Assemblies: Reductive Carbonylation of Nitrobenzenes

JACS Au, 2023
Jinhui Wang, Yanwei Cao, Qing-Wei Meng, Yaowei Wang, Huibing Shi, Baolin Feng, Yang Huang, Qi Sun, Lin He   +8 more
doaj   +1 more source