Results 141 to 150 of about 487,676 (263)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control. [PDF]

J Am Chem Soc
Mora M, Cohen G, Cranton W, Anton O, Beedle AEM, Stirnemann G, Garcia-Manyes S.   +6 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Reversible Enzymatic Switching of the Oxidation State of a Eu^III/II Complex Controls Relaxivity. [PDF]

J Am Chem Soc
Sarson ET, Cooper SM, Sedgwick AC, Berger AG, Twigger SA, Hammond EM, Vincent KA, Faulkner S.   +7 more
europepmc   +1 more source

The Highest Oxidation State of Rhodium: Rhodium(VII) in [RhO₃ ]. [PDF]

Angew Chem Int Ed Engl, 2022
da Silva Santos M, Stüker T, Flach M, Ablyasova OS, Timm M, von Issendorff B, Hirsch K, Zamudio-Bayer V, Riedel S, Lau JT.   +9 more
europepmc   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Steering Pt Cluster Dimensionality via the Surface Oxidation State of CeO₂(111) Thin Films. [PDF]

ACS Catal
Reich J, Soltanmohammadi M, Vonk V, Kaiser S, Heiz U, Stierle A, Esch F, Lechner BAJ.   +7 more
europepmc   +1 more source

Stability of Coumarins and Determination of the Net Iron Oxidation State of Iron-Coumarin Complexes: Implications for Examining Plant Iron Acquisition Mechanisms. [PDF]

ACS Earth Space Chem, 2023
Kang K, Schenkeveld WDC, Weber G, Kraemer SM.   +3 more
europepmc   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Covalent Bonding Between Ir and High-Oxidation State Sb Constrained by Quinoline Scaffolds. [PDF]

Inorg Chem
Kong F, Webber CK, Kumawat J, Quirion KP, Ou X, Dickie DA, Ess DH, Gunnoe TB.   +7 more
europepmc   +1 more source