Results 181 to 190 of about 2,950,856 (378)

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

open access: yesChemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay

open access: yesChemistry – A European Journal, EarlyView.
We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková   +11 more
wiley   +1 more source

Plant Phenylacetaldehyde Synthase Is a Bifunctional Homotetrameric Enzyme That Catalyzes Phenylalanine Decarboxylation and Oxidation [PDF]

open access: hybrid, 2006
Yasuhisa Kaminaga   +15 more
openalex   +1 more source

The Genuine Carbene Conundrum

open access: yesChemistry – A European Journal, Accepted Article.
Carbenes, these neutral divalent carbon species have emerged as pivotal players in our laboratories. Despite their broad impact, direct characterization of these reactive molecules remains challenging in many cases. This concept article draws on recent literature to explore the strengths and limitations of the most widely used strategies for their ...
Rodolphe Jazzar   +2 more
wiley   +1 more source

Intramolecular PCET of α‐Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals

open access: yesChemistry – A European Journal, EarlyView.
Decarboxylation of α‐keto acids have conventionally served as simple building blocks for the generation of nucleophilic acyl radicals. Herein, we demonstrate a distinct approach for this substrate class, showcasing the generation of ketyl radicals through a proton‐coupled electron transfer (PCET) mechanism.
Rifat N. Nabi   +4 more
wiley   +1 more source

A New Phenolic Acid Decarboxylase from the Brown-Rot Fungus Neolentinus lepideus Natively Decarboxylates Biosourced Sinapic Acid into Canolol, a Bioactive Phenolic Compound

open access: yesBioengineering
Rapeseed meal (RSM) is a cheap, abundant and renewable feedstock, whose biorefinery is a current challenge for the sustainability of the oilseed sector. RSM is rich in sinapic acid (SA), a p-hydroxycinnamic acid that can be decarboxylated into canolol (2,
Elise Odinot   +10 more
doaj   +1 more source

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