Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes. [PDF]
Mori T+10 more
europepmc +1 more source
The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork+3 more
wiley +1 more source
The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins+7 more
wiley +1 more source
Biogenic Amine Metabolism and Its Genetic Variations in Autism Spectrum Disorder: A Comprehensive Overview. [PDF]
Tabolacci C+6 more
europepmc +1 more source
The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma
ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun+5 more
wiley +1 more source
Effects of Nitro-Oxidative Stress on Biomolecules: Part 2-Reactive Molecular Dynamics Simulations. [PDF]
Chai Z+8 more
europepmc +1 more source
A study of the influence of thiamine and thiamine pyrophosphate on the anaerobic pyruvate metabolism of pig heart muscle [PDF]
Gruber, M., Meyer, F.D.G.
core +1 more source
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li+3 more
wiley +1 more source
Redefining the role of hypoxia-inducible factors (HIFs) in oxygen homeostasis. [PDF]
Arias CF+3 more
europepmc +1 more source