Results 111 to 120 of about 557,753 (336)

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

Betaine Treatment Attenuates Chronic Ethanol-Induced Hepatic Steatosis and Alterations to the Mitochondrial Respiratory Chain Proteome

International Journal of Hepatology, 2012
Introduction. Mitochondrial damage and disruption in oxidative phosphorylation contributes to the pathogenesis of alcoholic liver injury. Herein, we tested the hypothesis that the hepatoprotective actions of betaine against alcoholic liver injury occur ...
Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey   +7 more
doaj   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Neuronal oxidative injury in the development of the epileptic disease : a potential target for novel therapeutic approaches [PDF]

, 2011
Epileptic diseases affect about 50 million people in the world and approximately 30% of patients diagnosed with epilepsy are unresponsive to current medications.
Maio, Roberto di
core  

Uncouplers of oxidative phosphorylation. [PDF]

Environmental Health Perspectives, 1990
Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they ...
openaire   +3 more sources

RETRACTED: LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN [PDF]

, 2019
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao   +6 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source