Results 51 to 60 of about 1,290,914 (304)

Effect of reduced ambient pressure on weld formability, microstructure and corrosion behaviors in laser beam welding of zirconium alloy

Journal of Materials Research and Technology
Welding zirconium alloys is a critical challenge in the nuclear industry owing to their high sensitivity to hydrogen and oxygen at high temperatures. This study explored the feasibility of vacuum laser welding as an alternative to conventional electron ...
Lianfeng Wei, Yumo Jiang, Di Xie, Yong Zheng, Shengkui Zhang, Peicheng Lin, Meng Jiang, Xi Chen, Peng He, Yanbin Chen   +9 more
doaj   +1 more source

Fire Suppression of Gasoline Pool Fires Using Metal Oxide

Asian Journal of Applied Science and Technology, 2021
Fire suppressants have a great role in controlling fire accidents, with the use of proper fire suppressants, the loss can be greatly reduced. Metal oxides can be used as fire suppressants. A new type of dry powders with capsular structure is to be fabricated for fire suppression, in which the content of water approached 60%.
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Study on forming process and microstructure of FeCrAl-ODS alloy by selective laser melting

Journal of Materials Research and Technology
Powder preparation, forming process, microstructure, oxide particles, and precipitates of FeCrAl-ODS (Oxide Dispersion Strengthened) alloy fabricated by Selective Laser Melting (SLM) were systematically studied in this paper.
Shenghua Zhang, Fudong Li, Yu Wang, Zhonghua Li, Senming Zhang, Yen-Ling Kuo, Peikang Bai, Bin Liu   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Regulating heat input for additive manufacturing of oxide inclusions-free ODS-FeCrAl steel

Journal of Materials Research and Technology
Laser-based powder bed fusion (PBF-LB) of oxide dispersion strengthened (ODS)-FeCrAl steel commonly results in the generation of Y–Al–O oxide inclusions in the matrix.
Yanan Wang, Yan Peng, Binbin Wang, Baoxian Su, Liangshun Luo, Liang Wang, Yanqing Su, Jingjie Guo, Hengzhi Fu   +8 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy [PDF]

Molecular Pharmacology, 2015
NAD(+) kinase (NADK) is the only known cytosolic enzyme that converts NAD(+) to NADP(+), which is subsequently reduced to NADPH. The demand for NADPH in cancer cells is elevated as reducing equivalents are required for the high levels of nucleotide, protein, and fatty acid synthesis found in proliferating cells as well as for neutralizing high levels ...
Philip M, Tedeschi, HongXia, Lin, Murugesan, Gounder, John E, Kerrigan, Emine Ercikan, Abali, Kathleen, Scotto, Joseph R, Bertino   +6 more
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source