Results 301 to 310 of about 516,802 (337)

Minimally Modified LDL Is an Oxidized LDL Enriched with Oxidized Phosphatidylcholines

Journal of Biochemistry, 2003
The oxidative modification of low-density lipoprotein (LDL) is involved in atherogenesis. Among a variety of modified LDLs mentioned in the literature, so-called minimally modified LDL (MM-LDL) was reported to have pro-atherogenic properties despite minimal changes in its oxidative measures.
Yasuyuki Fujimoto, Yusuke Higashi, Tatsuya Takano, Masahiro Mori, Hiroyuki Itabe   +4 more
openaire   +2 more sources

Lectin-like Oxidized Low-Density Lipoprotein (LDL) Receptor (LOX-1): A Chameleon Receptor for Oxidized LDL.

Biochemistry, 2016
LOX-1, one of the main receptors for oxLDL, is found mainly on the surface of endothelial cells. It is a multifacet 52 kDa type II transmembrane protein that structurally belongs to the C-type lectin family.
B. Zeya, Albina Arjuman, N. Chandra
semanticscholar   +1 more source

LDL oxidation: therapeutic perspectives

Atherosclerosis, 1998
The peroxidation step of lipid transormation is considered to be essential in the pathogenesis of atherosclerosis. Although data concerning the mechanisms by which lipid peroxidation occurs in vivo are scarce, several lines of evidence suggest that some endogenous and exogenous compounds with antioxidant activity could have some beneficial effects in ...
F.R. Heller, Jean-Claude Hondekijn, Olivier S. Descamps   +2 more
openaire   +3 more sources

New Markers of Early Cardiovascular Risk in Multiple Sclerosis Patients: Oxidized-LDL Correlates with Clinical Staging

Disease Markers, 2013
OBJECTIVES: This study aimed to characterize a population of multiple sclerosis (MS) patients in terms of traditional and new cardiovascular risk factors and assess their putative correlation with clinical disease activity (evaluated by the Expanded ...
Filipe Palavra, Daniela Marado, Filipa Mascarenhas-Melo, J. Sereno, Edite Teixeira-Lemos, C. Nunes, Grilo Gonçalves, F. Teixeira, F. Reis   +8 more
semanticscholar   +1 more source

Immunological responses to oxidized LDL

Free Radical Biology and Medicine, 2000
Considerable evidence now points to an important role for the immune system in experimental models of atherosclerosis. We have reviewed the growing body of evidence that oxidation of LDL generates a wide variety of neoself determinants that lead to cellular and humoral immune responses.
Mi-Kyung Chang, Joseph L. Witztum, Peter X. Shaw, Christoph J. Binder, Gregg J. Silverman, Sohvi Hörkkö, Wulf Palinski   +6 more
openaire   +2 more sources

Metabolism of oxidized LDL by macrophages

Current Opinion in Lipidology, 2000
Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation?
Wendy Jessup, Leonard Kritharides
openaire   +3 more sources

Oxidation of LDL, Atherogenesis, and Apoptosis

Annals of the New York Academy of Sciences, 2003
Abstract: A plethora of studies in cultured cells have established that oxidized low‐density lipoprotein (oxLDL) may enhance arterial apoptosis that involves both mitochondrial and death receptor pathways (Fas/FasL, TNF receptors I and II), thereby activating caspase cascade and other proteases.
openaire   +4 more sources

Familial aggregation of LDL oxidation

Scandinavian Journal of Clinical and Laboratory Investigation, 1997
The "oxidation hypothesis" states that oxidative modification of low-density lipoprotein (LDL) is important in the pathogenesis of the atherosclerotic lesion. We studied 15 families (fathers, mothers and male twins of 16 to 18 years of age) to investigate the familial aggregation of LDL oxidation.
Matti J. Tikkanen, Jaakko Kaprio, Urho M. Kujala, Markku Ahotupa, Tommi Vasankari   +4 more
openaire   +3 more sources

In vitro oxidation of LDL by ozone

Chemistry and Physics of Lipids, 2014
Recent studies suggest that ozone is present in atherosclerotic lesions. Since these lesions are characterized by a dramatic accumulation of low-density lipoprotein (LDL), we aimed to investigate whether ozone is capable of oxidizing LDL, thereby rendering this lipoprotein atherogenic.
Martin Koestenberger, Erwin Tafeit, Gerd Hörl, Günther Jürgens, Gerhard Cvirn, Gerd Kager, Seth Hallström, Gerhard Ledinski   +7 more
openaire   +2 more sources

Oxidized LDL and Atherogenesis^a

Annals of the New York Academy of Sciences, 1999
Abstract: A brief review of recent findings regarding the role of oxidized low‐density lipoproteins (Ox‐LDL) in atherogenesis. Lipid peroxidation and oxidative damage to LDL make arteries susceptible to chronic inflammation, which is known to cause alterations in arterial gene expression and promote lesion development. Treatment protocols implementing
openaire   +3 more sources