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Role of Oxidized LDL in Atherosclerosis
Annals of the New York Academy of Sciences, 2001Abstract: A critical event in the early stages of atherosclerosis is the focal accumulation of lipid‐laden foam cells derived from macrophages. In various cholesterol‐fed animal models of atherosclerosis, localized attachment of circulating monocytes to arterial endothelial cells appeared to precede the formation of foam cells.
Toshinori Murayama +11 more
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Oxidation of LDL: Role in atherogenesis
Klinische Wochenschrift, 1991Oxidation of LDL is proposed to accelerate atherogenesis by the following sequence of events. LDL accumulates in atherosclerotic plaques, presumably due to interaction with intimal proteoglycans. The LDL then undergoes oxidation, and aldehydic products of lipid peroxidation such as HNE or other aldehyde products derived from lipid peroxidation, induce ...
J. A. O'Neil, H. F. Hoff
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Iron and LDL‐oxidation in atherogenesis.
APMIS, 1998It has been proposed that the development of atherosclerosis may be linked to the size of the body iron stores. The exact role of iron in the initiation and progression of atherogenesis is, however, still unknown. As a result of increasing support for the LDL‐oxidation hypothesis, much additional knowledge about the relation between iron and ...
Xi-Ming Yuan, Ulf T. Brunk
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2000
Oxidative stress is generally thought to play an important contributory role in the pathogenesis of atherosclerosis. Although there are many determinants in the development of this disease, substantial in vitro evidence links the production of oxidized forms of LDL to molecular processes involved in atherogenesis (1–7).
Balz Frei, Mark R. McCall
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Oxidative stress is generally thought to play an important contributory role in the pathogenesis of atherosclerosis. Although there are many determinants in the development of this disease, substantial in vitro evidence links the production of oxidized forms of LDL to molecular processes involved in atherogenesis (1–7).
Balz Frei, Mark R. McCall
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Oxidized LDL-Induced Apoptosis
2006There is now substantial evidence establishing that oxLDL and lipid peroxidation products generated in the vascular wall, can elicit proinflammatory and pathological events involved in atherosclerosis. As reported by D. Hajjar and M. Haberland, the oxLDL should be considered as true molecular “Trojan Horses” or “cellular saboteurs” bearing a lot of ...
Anne Nègre-Salvayre +2 more
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The Role of Oxidized LDL in Atherosclerosis
1990Atherosclerosis is a complex disease involving a variety of circulating blood components, lipoproteins, and their interactions with the cells and proteins of the extracellular matrix of the artery wall. The end stage lesion, which results in the occlusion of a vessel and/or provides a thrombogenic surface which leads to intravas cular thrombosis is ...
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Inhibition of LDL oxidation by antioxidants
1992Low density lipoprotein (LDL) consists of about 3000 fatty acids (50% polyunsaturated) and a single molecule apolipoprotein B (500 kDa). The endogenous antioxidants of LDL consist mainly of tocopherols and few carotenoids, which protect the PUFAS against oxidation.
Herbert Puhl +4 more
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Pharmaceutical research, 2000
The antioxidant activity of dihydropyridine calcium channel antagonists was evaluated based on LDL oxidation kinetics, oxidative cell injury associated with reactive species generation, and increases in free intracellular calcium (Ca2+) levels. Interactions with ascorbic acid were studied under conditions representative of LDL oxidation in plasma and ...
A. SEVANIAN, S. SHEN, URSINI, FULVIO
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The antioxidant activity of dihydropyridine calcium channel antagonists was evaluated based on LDL oxidation kinetics, oxidative cell injury associated with reactive species generation, and increases in free intracellular calcium (Ca2+) levels. Interactions with ascorbic acid were studied under conditions representative of LDL oxidation in plasma and ...
A. SEVANIAN, S. SHEN, URSINI, FULVIO
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Oxidation of LDL and extent of peripheral atherosclerosis
Free Radical Research, 1999Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age.
Vijver, L.P.L. van de +6 more
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Plasma Lipid Composition and LDL Oxidation
Clinical Chemistry and Laboratory Medicine, 2003Low-density lipoprotein (LDL) oxidation in vivo depends on lipid composition and on plasma antioxidant status. The aim of our study was to investigate the relationship between plasma lipid composition and LDL oxidation and, in particular, to explore whether LDL-cholesterol/triglycerides ratio (LDL-C/TG) and LDL-cholesterol/high-density lipoprotein (HDL)
BRIZZI P +5 more
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