Results 111 to 120 of about 505,050 (297)

Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipids

Platelets, 2002
Activated platelets adhere to the endothelium and release vasoactive mediators which induce vasoconstriction and remodeling of the vessel wall. The influence of native and ex vivo oxidized lipoproteins enriched with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC), the major lipid responsible for the biological activity of ...
Hartwich, Jadwiga, Dembińska-Kieć, Aldona, Gruca, Anna, Motyka, Marcin, Partyka, Lukasz, Skrzeczyńska-Moncznik, Joanna, Bzowska, Małgorzata, Pryjma, Juliusz, Huber, Joakim, Leitinger, Norbert, Schmitz, Gerd   +10 more
openaire   +3 more sources

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids

Journal of Lipid Research, 2007
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is present in oxidative modified LDL and accumulates in lesions of many chronic inflammatory diseases, such as atherosclerosis.
Rongsong Li, Wendy Chen, Rolando Yanes, Sangderk Lee, Judith A. Berliner   +4 more
doaj   +1 more source

Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library[S]

Journal of Lipid Research, 2017
Oxidized phospholipids (OxPLs) are widely held to be associated with various diseases, such as arteriosclerosis, diabetes, and cancer. To characterize the structure-specific behavior of OxPLs and their physiological relevance, we developed a ...
Ryohei Aoyagi, K. Ikeda, Yosuke Isobe, M. Arita   +3 more
semanticscholar   +1 more source

Biologically Active Oxidized Phospholipids [PDF]

Journal of Biological Chemistry, 1999
T M, McIntyre, G A, Zimmerman, S M, Prescott   +2 more
openaire   +2 more sources

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

The emerging roles of PAF acetylhydrolase

Journal of Lipid Research, 2009
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
Thomas M. McIntyre, Stephen M. Prescott, Diana M. Stafforini   +2 more
doaj   +1 more source

Role for Peroxisome Proliferator-Activated Receptor α in Oxidized Phospholipid–Induced Synthesis of Monocyte Chemotactic Protein-1 and Interleukin-8 by Endothelial Cells [PDF]

, 2000
Hans C. Lee, Weibin Shi, Peter Tontonoz, Shirley Wang, Ganesamoorthy Subbanagounder, Catherine C. Hedrick, Susan Hama, Christine Borromeo, Ronald M. Evans, Judith A. Berliner, László Nagy   +10 more
openalex   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Phospholipid oxidation generates potent anti‐inflammatory lipid mediators that mimic structurally related pro‐resolving eicosanoids by activating Nrf2

EMBO Molecular Medicine, 2015
Exposure of biological membranes to reactive oxygen species creates a complex mixture of distinct oxidized phospholipid (OxPL) species, which contribute to the development of chronic inflammatory diseases and metabolic disorders.
Peter Bretscher, Julian Egger, Abdijapar Shamshiev, Martin Trötzmüller, Harald Köfeler, Erick M Carreira, Manfred Kopf, Stefan Freigang   +7 more
doaj   +1 more source