Results 1 to 10 of about 1,706 (114)
Oxidopamine-Induced Nuclear Alterations Quantified Using Advanced Fractal Analysis: Random Forest Machine Learning Approach [PDF]
Fractal and Fractional, 2023 Fractal analysis (FA) is a contemporary computational technique that can assist in identifying and assessing nuanced structural alterations in cells and tissues after exposure to certain toxic chemical agents.
Igor Pantic +3 more
doaj +3 more sources
Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype [PDF]
Scientific Reports, 2017 AbstractCyclooxygenase-2 (COX-2) triggers pro-inflammatory processes that can aggravate neuronal degeneration and functional impairments in many neurological conditions, mainly via producing prostaglandin E2 (PGE2) that activates four membrane receptors, EP1-EP4. However, which EP receptor is the culprit of COX-2/PGE2-mediated neuronal inflammation and
Kang Xu +8 more
openalex +3 more sources
Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation
Advanced Science, Volume 10, Issue 18, June 23, 2023., 2023 During lactation, norepinephrine (NE) levels increase in cortical bone. In response, osteocytes increase Ca2+ signaling to promote the secretion of bone resorptive extracellular vesicles and cathepsin K (Ctsk) to degrade the perilacunar area bone matrix.
Qiaoyue Guo +9 more
wiley +1 more source
Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three
Siamak Reyhani-Rad, Javad Mahmoudi
doaj +2 more sources
Food Science &Nutrition, Volume 11, Issue 1, Page 168-180, January 2023., 2023 The hydro‐ethanolic extract of P. granatum peel was standardized. ;The extract increased superoxide dismutase activity and thiol content, while reduced function of AchE and peroxidation of lipid in the scopolamine‐injured rat’s brain. ;P. granatum may attenuate scopolamine injury through targeting nuclear factor‐E2‐related factor 2 pathway ; Abstract ...
Mahsan Akbarian +5 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023., 2023 MicroRNAs (miRNAs) are short, noncoding RNA transcripts. Mammalian miRNA coding sequences are located in introns and exons of genes encoding various proteins. As the central nervous system is the largest source of miRNA transcripts in living organisms, miRNA molecules are an integral part of the regulation of epigenetic activity in physiological and ...
Adam Szelągowski +2 more
wiley +1 more source
Chinese Medical Journal, 2017 Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in patients is due to the disease progression ...
Si-Yue Li +8 more
doaj +1 more source
Parkinson's Disease, Volume 2012, Issue 1, 2012., 2012 We discuss the participation of mitochondrial dynamics and autophagy in the 6‐hydroxidopamine‐induced Parkinson’s disease model. The regulation of dynamic mitochondrial processes such as fusion, fission, and mitophagy has been shown to be an important mechanism controlling cellular fate.
Maria F. Galindo +5 more
wiley +1 more source
The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases
Advanced Science, Volume 11, Issue 16, April 24, 2024.Despite significant research efforts, the knowledge about neurodegenerative disorder pathological processes and the development of efficacious drugs are still limited due to the inability to access and reproduce the intricated microenvironment of the nervous system.
Eleonora De Vitis +7 more
wiley +1 more source