Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases [PDF]
, 2017 The term "motor neuron disease" encompasses a spectrum of disorders in which motor neurons are the primary pathological target. However, in both patients and animal models of these diseases, not all motor neurons are equally vulnerable, in that while ...
Carella, Francesco +8 more
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International Union of Basic and Clinical Pharmacology: Differences and similarities between human and rodents concerning prostaglandin EP1-4 and IP receptors: Specific roles in pathophysiologic conditions [PDF]
, 2020 Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI(2)) and PGE(2) are strongly involved in the regulation of homeostasis and main physiologic functions. In addition,
Abdelazeem, Heba +14 more
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Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions [PDF]
, 2017 A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity.
Choong, Ferdinand Xiankeng
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Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing. [PDF]
, 2016 The protein Lin28 and microRNA let-7 play critical roles in mammalian development and human disease. Lin28 inhibits let-7 biogenesis through direct interaction with let-7 precursors (pre-let-7).
Balasubramanian, Shankar +2 more
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Analysis of hub genes temporal dynamics in cardiac ischemia/reperfusion injury: a bioinformatics and experimental study. [PDF]
Front PhysiolIntroductionMyocardial ischemia/reperfusion injury (MIRI) remains a major global health issue with rising morbidity and mortality. Blood flow restoration can worsen damage to oxygen-deprived cardiac tissue.
Zuo Y, Yang SY, Qian XK, Liu K.
europepmc +3 more sources
Research on Role of Connexin 36 in Pathogenesis of Rats with Levodopa-induced Dyskinesia
康复学报, 2016 Objective:To study the role of striatal connexin 36 (Cx36) in the pathogenesis of levodopa-induced dyskinesia (LID).Methods:A total of 60 SD rats were divided into the normal group, the sham operation group, the Parkinson's disease (PD) group, the ...
Bingtian ZHANG +4 more
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Avaliação do potencial redutor de gliose da CTK 01512-2, versão recombinante da toxina Phα1β isolada do veneno de Phoneutria nigriventer, em modelo de Doença de Parkinson em camundongos [PDF]
, 2021 A resposta neuroinflamatória é importante para a recuperação da homeostase. Porém, em estado intenso e crônico, pode ser prejudicial ao Sistema Nervoso Central.
Matheus Felipe Guimarães Aguiar
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Preclinical Evaluation of Water-Soluble Coenzyme Q10 for Therapeutic Treatment of Parkinson's Disease [PDF]
, 2012 Parkinson's disease is a common neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Mitochondrial dysfunction and oxidative stress are major contributors to this
Facecchia, Katie
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The treatment of Parkinson's disease using MAO-B inhibitors [PDF]
, 2017 Monoamine Oxidase Inhibitors have sparked great controversy in the treatment of idiopathic Parkinson’s Disease. There is little doubt that Monoamine Oxidase Inhibitors work synergistically with Levodopa to reduce several major debilitating symptoms ...
Parsons, Austin
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The role of adenosine monophosphate-activated protein kinase and mitogen-activated protein kinase p38 in autophagy and death induction in neuroblastoma cells treated with oxidopamine in vitro [PDF]
, 2021 Autofagija, razgradnja nepotrebnih/nefunkcionalnih unutarćelijskih komponenti u autolizozomima, kiselim organelama nastalim spajanjem autofagozoma i lizozoma, može biti citoprotektivna i citotoksična.
Arsikin Csordás, Katarina
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