Results 11 to 20 of about 173,579 (330)

Highly effective inhibition of biofilm formation by the first metagenome-derived AI-2 quenching enzyme

Frontiers in Microbiology, 2016
Bacterial cell-cell communication (quorum sensing, QS) represents a fundamental process crucial for biofilm formation, pathogenicity, and virulence allowing coordinated, concerted actions of bacteria depending on their cell density.
Nancy Weiland-Bräuer, Martin Johannes Kisch, Nicole Pinnow, Andreas Liese, Ruth Anne Schmitz-Streit   +4 more
doaj   +1 more source

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

eLife, 2020
Local structural frustration, the existence of mutually exclusive competing interactions, may explain why some proteins are dynamic while others are rigid. Frustration is thought to underpin biomolecular recognition and the flexibility of protein-binding
Lukas S Stelzl, Despoina AI Mavridou, Emmanuel Saridakis, Diego Gonzalez, Andrew J Baldwin, Stuart J Ferguson, Mark SP Sansom, Christina Redfield   +7 more
doaj   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Characterization of theThreshold for NAD(P)H:quinone Oxidoreductase Activity in Intact Sulforaphane-treated Pulmonary Arterial Endothelial Cells [PDF]

, 2011
Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5 μM, 24 h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact ...
Bongard, Robert D., Gastonguay, Adam J., Krenz, Gary S., Lindemer, Brian J., Merker, Marilyn P., Williams, Carol L.   +5 more
core   +2 more sources

Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/reductase able to catalyze cis-retinol oxidation

Journal of Lipid Research, 1999
We have identified a retinol dehydrogenase (cRDH) that catalyzes the oxidation of 9-cis- but not all-trans-retinol and proposed that this enzyme plays an important role in synthesis of the transcriptionally active retinoid, 9-cis-retinoic acid.
Mary V. Gamble, Enyuan Shang, Roseann Piantedosi Zott, James R. Mertz, Debra J. Wolgemuth, William S. Blaner   +5 more
doaj   +1 more source

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2015
OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew, Fairlamb, Alan, Foth, Bernado J., Kelner, Anna, Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +3 more sources

Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 Oxidoreductase deficiency [PDF]

, 2010
Context: P450 oxidoreductase (POR) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase.
Adachi, Antley, Arlt, Auchus, Belgorosky, Birgit Köhler, Bulun, Byskov, Cedric H. L. Shackleton, Dharia, Dhir, Dominique Maiter, Ewa M. Malunowicz, Falhammar, Felicity Collins, Flück, Fujieda, Fukami, Fukami, Fukami, Grondahl, Grøndahl, Hague, Huang, Huang, Idkowiak, Jan Idkowiak, Jin, Krone, Latronico, Luitgard Margarete Graul-Neumann, Mallin, Mann, Maria Szarras-Czapnik, Martin Silink, Mehul Dattani, Michiel N. Kerstens, Mullis, New, Nguyen, Nicole Reisch, Nils Krone, Otto, Ribes, Rosa, Roux, Rozman, Sahakitrungruang, Schmidt, Shackleton, Shima, Stephen O'Riordan, Suzuki, Tanae, ten Kate-Booij, Tomalik-Scharte, Wang, Wang, Wiebke Arlt, Wilson   +59 more
core   +2 more sources

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]

, 2020
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A., DeNicola, Gina M., Elkins, Cody M., Falzone, Aimee, Haura, Eric B., Prieto-Farigua, Nicolas, Torrente, Laura   +6 more
core   +1 more source

Evaluation of Interactions of Added Soybean Peroxidase with Other Nutrients Present in Fish Feeds Using an In Vitro Digestive Simulation

Animals, 2023
Peroxidase (PO) has been applied in different areas of industrial biotechnology, including the control of contaminants like aflatoxin B1 in fish feeds.
Wesclen Vilar Nogueira, María Jesús Aznar-García, Francisca P. Martínez-Antequera, Antonia M. Barros de Las Heras, Marcelo Borges Tesser, Jaqueline Garda-Buffon, Francisco Javier Moyano   +6 more
doaj   +1 more source

Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase [PDF]

, 2017
No abstract ...
Norman, Jim, Zanivan, Sara
core   +1 more source