Results 11 to 20 of about 154,492 (238)

Systems-Based Design of Bi-Ligand Inhibitors of Oxidoreductases: Filling the Chemical Proteomic Toolbox [PDF]

, 2004
Genomics-driven growth in the number of enzymes of unknown function has created a need for better strategies to characterize them. Since enzyme inhibitors have traditionally served this purpose, we present here an efficient systems-based inhibitor design
Baker, Brian, Bertolaet, Bonnie, Chang, Edcon, Costache, Aurora Demertrina, Coutts, Stephen, Dong, Qing, Hansen, Mark, Hong, Victor, Huang, Xuemei, Jack, Richard M., Kho, Richard, Lang, Henk, Ma, Chen-Ting, Meininger, David, Pellacchia, Maurizio, Pierre, Fabrice, Sem, Daniel S., Villar, Hugo, Yu, Lin   +18 more
core   +2 more sources

Time-course RNA-seq analysis provides an improved understanding of genetic regulation in response to cold stress from white clover (Trifolium repens L.)

Biotechnology & Biotechnological Equipment, 2022
White clover (Trifolium repens L.) is an important legume forage, which is widely distributed in cool-season regions. Therefore, cold stress is a major environmental factor limiting its growth and production, while little is known about the its cold ...
Xueqi Zhang, Huanhuan Yang, Manman Li, Chao Chen, Yan Bai, Donglin Guo, Changhong Guo, Yongjun Shu   +7 more
doaj   +1 more source

Physiological function and catalytic versatility of bacterial multihaem cytochromescinvolved in nitrogen and sulfur cycling [PDF]

, 2011
Bacterial MCCs (multihaem cytochromes c) represent widespread respiratory electron-transfer proteins. In addition, some of them convert substrates such as nitrite, hydroxylamine, nitric oxide, hydrazine, sulfite, thiosulfate or hydrogen peroxide. In many
Arslan, Atkinson, Bayachou, Bianca Hermann, Campbell, Clarke, Costa, de Almeida, Eaves, Einsle, Einsle, Frawley, Hartshorne, Hartshorne, Henson, Hoffmann, Igarashi, Julea N. Butt, Jörg Simon, Kemp, Kern, Kern, Kern, Kern, Kern, Klotz, Kostera, Kostera, Kranz, Londer, Lukat, Marritt, Melanie Kern, Mills, Mowat, Mowat, Oliver Einsle, Pereira, Pisa, Pittman, Poock, Rudolf, Schalk, Sharma, Shimamura, Shimamura, Shirodkar, Simon, Simon, Simon, Sorokin, Stach, Strous, Tikhonova, van Wonderen   +54 more
core   +1 more source

Pharmacogenomics of human P450 oxidoreductase [PDF]

Frontiers in Pharmacology, 2014
Cytochrome P450 oxidoreductase (POR) supports reactions of microsomal cytochrome P450 which metabolize drugs and steroid hormones. Mutations in POR cause disorders of sexual development. P450 oxidoreductase deficiency (PORD) was initially identified in patients with Antley-Bixler syndrome (ABS) but now it has been established as a separate disorder of ...
Patrick Sproll, Amit V. Pandey, Amit V. Pandey   +2 more
openaire   +6 more sources

Highly effective inhibition of biofilm formation by the first metagenome-derived AI-2 quenching enzyme

Frontiers in Microbiology, 2016
Bacterial cell-cell communication (quorum sensing, QS) represents a fundamental process crucial for biofilm formation, pathogenicity, and virulence allowing coordinated, concerted actions of bacteria depending on their cell density.
Nancy Weiland-Bräuer, Martin Johannes Kisch, Nicole Pinnow, Andreas Liese, Ruth Anne Schmitz-Streit   +4 more
doaj   +1 more source

Protein disulfide isomerase a multifunctional protein with multiple physiological roles

Frontiers in Chemistry, 2014
Protein disulfide isomerase (PDI), is a member of the thioredoxin superfamily of redox proteins. PDI has three catalytic activities including, thiol-disulfide oxireductase, disulfide isomerase and redox-dependent chaperone.
Hyder eAli Khan, Bulent eMutus
doaj   +1 more source

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

eLife, 2020
Local structural frustration, the existence of mutually exclusive competing interactions, may explain why some proteins are dynamic while others are rigid. Frustration is thought to underpin biomolecular recognition and the flexibility of protein-binding
Lukas S Stelzl, Despoina AI Mavridou, Emmanuel Saridakis, Diego Gonzalez, Andrew J Baldwin, Stuart J Ferguson, Mark SP Sansom, Christina Redfield   +7 more
doaj   +1 more source

Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. [PDF]

, 2009
Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and ...
Berkel, W.J.H., van, Eulberg, D., Kaschabek, S.R., Lakner, S., Schloemann, M., Tischler, D.   +5 more
core   +4 more sources

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Lung Injury and Oxidoreductases

Environmental Health Perspectives, 1998
Acute lung injury represents a wide spectrum of pathologic processes, the most severe end of the spectrum being the acute respiratory distress syndrome. Reactive oxygen intermediates have been implicated as important in the pathobiochemistry of acute lung injury.
Anne Sturrock, T. P. Huecksteadt, Karl Sanders, Kathleen D. Pfeffer, Ping Xu, John R. Hoidal   +5 more
openaire   +3 more sources