Results 11 to 20 of about 127,380 (196)
Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview
Medical Science Monitor, 2016 Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS).
Changyi J. Chen, Jianming Lü, Q. Yao
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Applications of Oxidoreductases
, 2021 Oxidoreductases comprise of a large group of enzymes catalyzing the transfer of electrons from an electron donor to an electron acceptor molecule, commonly taking nicotinamide adenine dinucleotide phosphate (NADP) or nicotinamide adenine dinucleotide (NAD) as cofactors.
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Oxidoreductase-Catalyzed Synthesis of Chiral Amines
ACS Catalysis, 2018 Chiral amines are valuable constituents of many important pharmaceutical compounds and their intermediates. It is estimated that ∼40%–45% of small molecule pharmaceuticals contain chiral amine scaffolds in their structures.
M. Patil +3 more
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Journal of Biological Chemistry, 2015 Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10.
B. Kelly +3 more
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Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
Nature Communications, 2017 The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs).
J. Hernandez-Fernaud +28 more
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Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects
Oxidative Medicine and Cellular Longevity, 2015 Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species.
M. Battelli +3 more
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The ascent of man(made oxidoreductases)
Current Opinion in Structural Biology, 2018 Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules ...
Grayson, Katie, Anderson, Ross
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mBio, 2017 Dengue virus (DENV) is the most common arboviral infection globally, infecting an estimated 390 million people each year. We employed a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen to identify host dependency ...
D. L. Lin +5 more
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The Thermodynamics of Xanthine Oxidoreductase Catalysis [PDF]
Antioxidants & Redox Signaling, 1999 Xanthine oxidoreductase is a complex enzyme found in a wide range of organisms. Recent interest in this enzyme stems from its ability to produce reactive oxygen species under a range of conditions. It is found as a homodimer, each unit containing a molybdopterin cofactor, two iron sulfur centers, and FAD.
Sanders, Stephen A., Massey, Vincent
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Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Nature Communications, 2015 Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by
A. Ives +8 more
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