Results 81 to 90 of about 154,492 (238)

Cyclic AMP Receptor Protein from Yeast Mitochondria [PDF]

, 1985
We have identified and characterized a cyclic AMP receptor protein in mitochondria of the yeast Saccharomyces cerevisiae. The binding is specific for cyclic nucleotides, particularly for cyclic AMP which is bound with high affinity (Kd of 10(-9) M) at 1 ...
Bandlow, Wolfhard, Müller, Günter, Rödel, Gerhard   +2 more
core  

The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide

MedComm
Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological situations and
Shijian Feng, Xiaofang Huang, Dan Tang, Xiaoyu Liu, Liang Ouyang, Dehua Yang, Kunjie Wang, Banghua Liao, Shiqian Qi   +8 more
doaj   +1 more source

N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells [PDF]

, 2019
Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides
Forte, Elena, Giardina, Giorgio, Giuffrè, Alessandro, Malagrinò, Francesca, Masi, Letizia, Paulini, Giulia, Tomé, Catarina S, Vicente, João B, Zuhra, Karim   +8 more
core   +2 more sources

A strategy for identification and characterization of genic mutations using a temperature‐sensitive chlorotic soybean mutant as an example

Plant Direct
Screening a transposon‐mutagenized soybean population led to the discovery of a recessively inherited chlorotic phenotype. This “y24” phenotype results in smaller stature, weaker stems, and a smaller root system. Genome sequencing identified 15 candidate
C. Nathan Hancock, Tetandianocee Germany, Priscilla Redd, Jack Timmons, Jeffery Lipford, Samantha Burns, Sergio Alan Cervantes‐Perez, Marc Libault, Wenhao Shen, Yong‐qiang Charles An, Lisa Kanizay, Melinda Yerka, Wayne A. Parrott   +12 more
doaj   +1 more source

Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes

Frontiers in Microbiology, 2018
Twelve evolutionarily unrelated oxidoreductases form enzyme complexes that catalyze the simultaneous coupling of exergonic and endergonic oxidation–reduction reactions to circumvent thermodynamic barriers and minimize free energy loss in a process known ...
Saroj Poudel, Eric C. Dunham, Melody R. Lindsay, Maximiliano J. Amenabar, Elizabeth M. Fones, Daniel R. Colman, Eric S. Boyd   +6 more
doaj   +1 more source

Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling [PDF]

, 2012
Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present
Cupitt, John, Edwards, Robert J., Fritsche, Ellen, Gierula, Magdalena, Götz, Christine, Rodrigues-Lima, Fernando, van Eijl, Sven, Zhu, Zheying   +7 more
core   +3 more sources

The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen [PDF]

, 2014
BACKGROUND: The facultatively anaerobic betaproteobacterium Castellaniella defragrans 65Phen utilizes acyclic, monocyclic and bicyclic monoterpenes as sole carbon source under oxic as well as anoxic conditions.
Becher, D., Disch, E., Harder, J., Huettel, B., Markert, S., Petasch, J., Reinhardt, R., Schweder, T.   +7 more
core   +2 more sources

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

Molecules, 2015
Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common applications include lead identification and scaffold hopping, as well as lead optimization by structure-activity ...
Teresa Kaserer, Katharina R. Beck, Muhammad Akram, Alex Odermatt, Daniela Schuster   +4 more
doaj   +1 more source

Electrodes modified with lipid membranes to study quinone oxidoreductases

, 2009
Quinone oxidoreductases are a class of membrane enzymes that catalyse the oxidation or reduction of membrane-bound quinols/quinones. The conversion of quinone/quinol by these enzymes is difficult to study because of the hydrophobic nature of the enzymes ...
Jeuken, LJC, Weiss, SA
core   +1 more source

Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2002
A comprehensive phylogenetic analysis of the core subunits of succinate:quinone oxidoreductases and quinol:fumarate oxidoreductases is performed, showing that the classification of the enzymes as type A to E based on the type of the membrane anchor fully correlates with the specific characteristics of the two core subunits.
Cláudio M. Gomes, Rita S. Lemos, Andreia S. Fernandes, Manuela M. Pereira, Miguel Teixeira   +4 more
openaire   +3 more sources