Results 1 to 10 of about 6,929 (107)
Theranostics, 2021 N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m6A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneration ...
Zhenbo Han +28 more
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Polymer coated cerium oxide nanoparticles as oxidoreductase-like catalysts [PDF]
ACS Appl. Mater. Interfaces 2020, 12, 37, 42056 - 42066, 2020 Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, harmful molecules produced in oxidative stress asso-ciated diseases.
arxiv +1 more source
Oxidoreductases in Glycoprotein Glycosylation, Folding, and ERAD
Cells, 2020 N-linked glycosylation and sugar chain processing, as well as disulfide bond formation, are among the most common post-translational protein modifications taking place in the endoplasmic reticulum (ER).
Chaitanya Patel +3 more
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Japanese Journal of Pharmacology, 1968 In previous papers, it was reported that aminopyrine N-demethylating activity of liver microsomes in male rats was markedly decreased under unphysiological conditions, such as, starvation, alloxan dia betes, adrenalectomy and administration of morphine ...
R. Kato, A. Takanaka, K. Onoda
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PLoS ONE, 2014 The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central for resistance to polymyxin.
S. Piek +12 more
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The NAD(P)H:flavin oxidoreductase from Escherichia coli. Evidence for a new mode of binding for reduced pyridine nucleotides [PDF]
The journal of biological chemistry, American Society for
Biochemistry and Molecular Biology, 1999, 274, pp.18252-60, 2015 The NAD(P)H:flavin oxidoreductase from Escherichia coli, named Fre, is a monomer of 26.2 kDa that catalyzes the reduction of free flavins using NADPH or NADH as electron donor. The enzyme does not contain any prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin in a ternary complex prior to oxidoreduction.
arxiv +1 more source
The mechanism of catalysis by type-II NADH:quinone oxidoreductases
Scientific Reports, 2017 Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional respiratory complex I in ...
J. N. Blaza +7 more
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PLoS ONE, 2013 The prognosis of acute myeloid leukemia (AML) in elderly (≥65 years) patients is poor and treatment remains non-consensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (
E. Paubelle +13 more
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A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor [PDF]
The journal of biological chemistry, American Society for
Biochemistry and Molecular Biology, 2004, 279, pp.44362-9, 2015 The two-component flavin-dependent monooxygenases belong to an emerging class of enzymes involved in oxidation reactions in a number of metabolic and biosynthetic pathways in microorganisms. One component is a NAD(P)H:flavin oxidoreductase, which provides a reduced flavin to the second component, the proper monooxygenase.
arxiv +1 more source
Journal of the National Cancer Institute, 2014 BACKGROUND Acute myeloid leukemia (AML) therapy has limited long-term efficacy because patients frequently develop disease relapse because of the inability of standard chemotherapeutic agents to target AML stem/progenitor cells.
B. Carter +13 more
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