Results 11 to 20 of about 6,948 (126)

Microbial degradation of plant toxins

Environmental Microbiology, Volume 25, Issue 12, Page 2988-3010, December 2023., 2023
Plants produce a variety of secondary metabolites. This review summarizes the knowledge on microbial degradation of those metabolites with a focus on the genes and enzymes involved in the biodegradation pathways. Knowledge gaps and possible biotechnological applications of plant metabolite degrading microorganisms are highlighted.
Magda A. Rogowska‐van der Molen, Aileen Berasategui‐Lopez, Silvia Coolen, Robert S. Jansen, Cornelia U. Welte   +4 more
wiley   +1 more source

Roles and implications of mRNA N6‐methyladenosine in cancer

Cancer Communications, Volume 43, Issue 7, Page 729-748, July 2023., 2023
Abstract RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention. To date, m6A modification has been shown to impact multiple RNA metabolic processes and play a vital role in numerous biological processes.
Lingxing Zeng, Xudong Huang, Jialiang Zhang, Dongxin Lin, Jian Zheng   +4 more
wiley   +1 more source

Adaptive genetic traits in pelagic freshwater microbes

Environmental Microbiology, Volume 25, Issue 3, Page 606-641, March 2023., 2023
Abstract Pelagic microbes have adopted distinct strategies to inhabit the pelagial of lakes and oceans and can be broadly categorized in two groups: free‐living, specialized oligotrophs and patch‐associated generalists or copiotrophs. In this review, we aim to identify genomic traits that enable pelagic freshwater microbes to thrive in their habitat ...
Maria‐Cecilia Chiriac, Markus Haber, Michaela M. Salcher   +2 more
wiley   +1 more source

Metabolism of sumatriptan revisited

Pharmacology Research &Perspectives, Volume 11, Issue 1, February 2023., 2023
Proposed metabolic pathway of sumatriptan. Abstract Scientific literature describes that sumatriptan is metabolized by oxidative deamination of its dimethylaminoethyl residue by monoamine oxidase A (MAO A) and not by cytochrome P450 (CYP)‐mediated demethylation, as is usual for such structural elements.
Timo Pöstges, Matthias Lehr
wiley   +1 more source

Highly Accessible Computational Prediction and In Vivo/In Vitro Experimental Validation: Novel Synthetic Phenyl Ketone Derivatives as Promising Agents against NAFLD via Modulating Oxidoreductase Activity

Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023., 2023
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions with no pharmacological treatment approved. Several highly accessible computational tools were employed to predict the activities of twelve novel compounds prior to actual chemical synthesis.
Yanan Qiao, Huifang Deng, Lihua Liu, Shuran Liu, Luyao Ren, Chuandao Shi, Xi Chen, Lixia Guan, Weiran Liu, Zehua Li, Yunlan Li, Daniel Dias Rufino Arcanjo   +11 more
wiley   +1 more source

An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment

Cancer Communications, Volume 42, Issue 11, Page 1083-1111, November 2022., 2022
Abstract Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain tumor. Patients with GBM often have poor prognoses, with a median survival of ∼15 months. Enhanced understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications, the most recent of which classified
Elena Verdugo, Iker Puerto, Miguel Ángel Medina   +2 more
wiley   +1 more source

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

Riboflavin integrates cellular energetics and cell cycle to regulate maize seed development

Plant Biotechnology Journal, Volume 20, Issue 8, Page 1487-1501, August 2022., 2022
Summary Riboflavin is the precursor of essential cofactors for diverse metabolic processes. Unlike animals, plants can de novo produce riboflavin through an ancestrally conserved pathway, like bacteria and fungi. However, the mechanism by which riboflavin regulates seed development is poorly understood.
Qiuzhen Tian, Gang Wang, Xuexia Ma, Qingwen Shen, Mengli Ding, Xueyi Yang, Xiaoli Luo, Rongrong Li, Zhenghui Wang, Xiangyang Wang, Zhiyuan Fu, Qinghua Yang, Jihua Tang, Guifeng Wang   +13 more
wiley   +1 more source

Glycine betaine uptake and metabolism in marine microbial communities

Environmental Microbiology, Volume 24, Issue 5, Page 2380-2403, May 2022., 2022
Summary Glycine betaine (GBT) is a compatible solute in high concentrations in marine microorganisms. As a component of labile organic matter, GBT has complex biochemical potential as a substrate for microbial use that is unconstrained in the environment.
Angela K. Boysen, Bryndan P. Durham, William Kumler, Rebecca S. Key, Katherine R. Heal, Laura T. Carlson, Ryan D. Groussman, E. Virginia Armbrust, Anitra E. Ingalls   +8 more
wiley   +1 more source

Energy‐conserving dimethyl sulfoxide reduction in the acetogenic bacterium Moorella thermoacetica

Environmental Microbiology, Volume 24, Issue 4, Page 2000-2012, April 2022., 2022
Summary Moorella thermoacetica is one of the well‐studied thermophilic acetogenic bacteria. It grows by oxidation of organic substrates, CO or H2 coupled to CO2 reduction to acetate. Here, we describe that M. thermoacetica can also use dimethyl sulfoxide as terminal electron acceptor. Growth of M.
Florian P. Rosenbaum, Anja Poehlein, Rolf Daniel, Volker Müller   +3 more
wiley   +1 more source