Results 41 to 50 of about 6,948 (126)
MedComm, Volume 5, Issue 6, June 2024.Relationships between immune cell metabolism, epigenetics modulation, and cancer immunotherapy clinical efficiency. Epigenetic regulation (including DNA methylation, RNA methylation, histone modification, and chromatin remodeling) of immune cells can influence the differentiation and activity of immune cells, while metabolic status influences the ...
Sha Qin +8 more
wiley +1 more source
Tailoring modifications in labrenzin synthesis: a‐la‐carte production of pathway intermediates
Microbial Biotechnology, Volume 17, Issue 1, January 2024.In this work, we study the role of tailoring enzymes from the lab gene cluster responsible for methylation and hydroxylation of labrenzin, a pederin‐family molecule. By expressing them heterologously, we managed to produce a spectrum of differently tailored labrenzin analogs in Labrenzia sp. PHM005.
Dina Kačar +6 more
wiley +1 more source
Abstract Book for the 27th Congress of the European Hematology Association
, 2022 HemaSphere, Volume 6, Issue S3, Page 1-4130, June 2022.
wiley +1 more source
European Journal of Biochemistry, 2004 Nicotine catabolism, linked in Arthrobacter nicotinovorans to the presence of the megaplasmid pAO1, leads to the formation of gamma-N-methylaminobutyrate from the pyrrolidine ring of the alkaloid.
Calin B. Chiribau +4 more
semanticscholar +1 more source
European Journal of Biochemistry, 1973 The interaction of substrates with a 4-methoxybenzoate O-demethylating enzyme system was studied by use of crude cell-free extracts and also by the purified enzyme system.
F. Bernhardt +3 more
semanticscholar +1 more source
Antioxidants and Redox Signaling, 2012 AIMS Redox regulation of cellular processes is an important mechanism that operates in organisms from bacteria to mammals. Much of the redox control is provided by thiol oxidoreductases: proteins that employ cysteine residues for redox catalysis.
D. Fomenko, V. Gladyshev
semanticscholar +1 more source
Epigenetics of SFRP1: The Dual Roles in Human Cancers
Cancers, 2020 Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to the loss of expression in various human cancers, which is mainly attributed by ...
Rashidah Baharudin +3 more
semanticscholar +1 more source
Banana skin: a novel material for a low-cost production of laccase [PDF]
arXiv, 2008 Laccases (benzenodiol: oxygen oxidoreductases; EC 1.10.3.2) are multicopper oxidases of wide substrate specificity mainly found in white-rot fungi, which are the only microorganisms able to degrade the whole wood components, but they are also expressed in bacteria and higher plants. Laccases are used currently in biotechnological processes because this
arxiv
Multi-scale Molecular Simulations on Respiratory Complex I [PDF]
Chemical Biology No. 5 (2018), 2019 Complex I (NADH:ubiquinone oxidoreductase) is a redox-driven proton pump that powers synthesis of adenosine triphosphate (ATP) and active transport in most organisms. This gigantic enzyme reduces quinone (Q) to quinol (QH2) in its hydrophilic domain, and transduces the released free energy into pumping of protons across its membrane domain, up to ca ...
arxiv
Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
Journal of the National Cancer Institute, 2003 BACKGROUND Gene silencing by abnormal methylation of promoter regions of regulatory genes is commonly associated with cancer. Silenced tumor suppressor genes are obvious targets for reactivation by methylation inhibitors such as 5-azacytidine (5-Aza-CR ...
Jonathan C. Cheng +7 more
semanticscholar +1 more source