Results 21 to 30 of about 2,903 (131)

ThYme: a database for thioester-active enzymes [PDF]

, 2010
The ThYme (Thioester-active enzYme; http://www.enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis ...
Berman, Cantu, D. C. Cantu, Durrett, Fischer, Gasteiger, Hotelier, M. L. Lemons, Murzin, Nikolau, P. J. Reilly, Y. Chen, Ye   +12 more
core   +4 more sources

The pyruvate and α-ketoglutarate dehydrogenase complexes of Pseudomonas aeruginosa catalyze pyocyanin and phenazine-1-carboxylic acid reduction via the subunit dihydrolipoamide dehydrogenase [PDF]

, 2017
Phenazines are a class of redox-active molecules produced by diverse bacteria and archaea. Many of the biological functions of phenazines, such as mediating signaling, iron acquisition, and redox homeostasis, derive from their redox activity.
Glasser, Nathaniel R., Hoy, Julie A., Newman, Dianne K., Wang, Benjamin X.   +3 more
core   +1 more source

Repetitive and Non-Repetitive DNA Sequences and a Speculation on the Origins of Evolutionary Novelty [PDF]

, 1971
Recent experimental information on DNA sequence repetition is reviewed, and the significance of both repetitive and non-repetitive sequence considered.
Britten, Roy J., Davidson, Eric H.
core   +1 more source

Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]

, 2016
This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abo-Hamad, Amelio, Aparicio, Assanosi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Bafti, Bakavoli, Beckman, Bednarz, Borse, Cao, Cardellini, Carriazo, Chahdoura, Chai, Chaskar, Chen, Chen, Constable, Cragg, Dai, Dai, Dai, Dai, Davey, De Oliveira Vigier, De Oliveira Vigier, De Santi, del Monte, Disale, Domínguez de María, Domínguez de María, Duan, Dupont, Durand, Díaz-Álvarez, Earle, Ferreira, Fischer, Francisco, Gambino, García, García-Verdugo, García-Álvarez, García-Álvarez, Gill, Gore, Gorke, Gu, Guajardo, Gupta, Hallet, Handy, Handy, Handy, Hari, Hawkins, Hayyan, Henderson, Hu, Hu, Ilgen, Ilgen, Imperato, Imperato, Imperato, Itoh, Jella, Jérôme, Karmakar, Kemeling, Keshavarzipour, Khandelwal, Krishnakumar, Kumar, Kus, Laird, Lavilla, Li, Li, Li, Li, Lindström, Liu, Liu, Liu, Lobo, Lobo, Lu, Macaev, Machida, Mahboub, Mallardo, Martins, Matsuda, Maugeri, Maugeri, Maugeri, Mobinikhaledi, Morales, More, Müller, Müller, Pace, Pal, Pandey, Patil, Pavia, Pawar, Pednekar, Pena-Pereira, Pena-Pereira, Peters, Phadtare, Phadtare, Pincock, Pérez, Pérez-Sánchez, Radošević, Rastogi, Reddy, Rodríguez-Álvarez, Ruß, Saberi, Sanap, Sanap, Santos, Sassone, Scholten, Serrano, Sheldon, Shuklov, Singh, Singh, Singh, Singh, Singh, Smith, Sonawane, Steinrück, Stepankova, Sunitha, Tanaka, Tang, Tang, Vidal, Vidal, Vidal, Wagle, Wang, Wang, Wang, Wang, Wang, Wang, Wasserscheid, Welton, Xia, Yadav, Yadav, Yadav, Yu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao   +192 more
core   +2 more sources

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]

, 2010
The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang   +124 more
core   +3 more sources

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source