Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells. [PDF]
, 2023 PURPOSE This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells.
Alini, Mauro +14 more
core +2 more sources
Engineered surface strategies to manage dental implant‐related infections
Periodontology 2000, EarlyView.Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza +7 more
wiley +1 more source
Chemogenomics of pyridoxal 5′-phosphate dependent enzymes [PDF]
, 2011 Pyridoxal 5'-phosphate (PLP) dependent enzymes comprise a large family that plays key roles in amino acid metabolism and are acquiring an increasing interest as drug targets.
Alessandro Paiardini +5 more
core +1 more source
Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism [PDF]
, 2017 Background: Microbes, plants, and fungi synthesize an enormous number of metabolites exhibiting rich chemical diversity. For a high-level classification, metabolism is subdivided into primary (PM) and secondary (SM) metabolism.
Heizinger, Leonhard +3 more
core +4 more sources
Genetic control of wheat flour end‐use quality and rheology by genome‐wide association studies
The Plant Genome, Volume 19, Issue 2, June 2026.Abstract Improving end‐use quality in bread wheat (Triticum aestivum) requires dissecting the genetic basis of complex processing traits and deploying robust prediction pipelines in breeding. We performed genome‐wide association studies (GWASs) using 1767 high‐quality single‐nucleotide polymorphisms generated by genotyping‐by‐sequencing in a diverse ...
Juan Menor de Gaspar +10 more
wiley +1 more source
Modification of cysteine residues by cyclopentenone prostaglandins: Interplay with redox regulation of protein function [PDF]
, 2014 40 p.-5 fig.-1 tab.Cyclopentenone prostaglandins (cyPG) are endogenous lipid mediators involved in the resolution of inflammation and the regulation of cell proliferation and cellular redox status. Upon exogenous administration they have shown beneficial
Oeste, Clara L., Pérez Sala, Dolores
core +1 more source
Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms
Food Frontiers, Volume 7, Issue 3, May 2026.Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang +4 more
wiley +1 more source
Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Riboflavin (RF, vitamin B2) is an essential vitamin of which the co‐factors are critical to numerous cellular processes. RF is used as a treatment for inherited metabolic diseases (IMDs), although its effectiveness in many disorders has not been established.
Bregje Jaeger +7 more
wiley +1 more source
Divergent functional isoforms drive niche specialisation for nutrient acquisition and use in rumen microbiome [PDF]
, 2017 Many microbes in complex competitive environments share genes for acquiring and utilising nutrients, questioning whether niche specialisation exists and if so, how it is maintained.
A McKenna +71 more
core +3 more sources
Microbial Biotechnology, Volume 19, Issue 5, May 2026.Multi‐enzyme systems from Tenebrio molitor enable solvent‐free recovery of microbial PHAs directly from wet biomass under mild aqueous conditions, achieving high polymer yields and integrity while reducing carbon footprint up to seven‐fold compared with conventional extraction methods.
Sanja Skaro Bogojevic +12 more
wiley +1 more source