Results 21 to 30 of about 1,997 (90)
From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe +5 more
wiley +1 more source
The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
New Phytologist, Volume 251, Issue 3, Page 1267-1282, August 2026.Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Licheng Liu +19 more
wiley +1 more source
The Plant Journal, Volume 127, Issue 4, August 2026.SUMMARY Dioscorea alata L., the most widely cultivated yam species, exhibits dioecy (XY system) and a strong male‐biased sex ratio. These two major constraints limit parental combinations and hinder breeding progress. To get insight into the sex chromosome structure and evolution in D.
Komivi Dossa +20 more
wiley +1 more source
Advanced Functional Materials, Volume 36, Issue 60, 27 July 2026.Innovative hybrid nanoassemblies installed with ferrocene, D‐α‐tocopherol succinate, and phloretin exploit the metabolic vulnerability of triple‐negative breast cancer under glucose starvation. By blocking glucose uptake, this single nanoplatform simultaneously orchestrates apoptosis, disulfidptosis, and ferroptosis to achieve synergistic and ...
Song Yi Lee +10 more
wiley +1 more source
Biomethane Energy Production Using Orange Hydrogen Coupled With CO2 Sequestration and Utilization
Carbon Neutralization, Volume 5, Issue 4, July 2026.In subsurface hydrocarbon‐simulated environments, injected CO2 follows dual transformation routes: geochemical mineralization into stable carbonates (CCS) and microbially mediated conversion into CH4 energy through anaerobic metabolic processes. ABSTRACT The escalating concerns of global warming have intensified the global demand for clean energy ...
Muhammad Javed +12 more
wiley +1 more source
Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest +6 more
wiley +1 more source
Transcriptome changes of fission yeast cells exposed to fumonisin B1 or co-cultured with Fusarium verticillioides. [PDF]
Appl Microbiol BiotechnolPapp LA +7 more
europepmc +1 more source