Results 31 to 40 of about 2,903 (131)

Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells. [PDF]

open access: yes, 2023
PURPOSE This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells.
Alini, Mauro   +14 more
core   +2 more sources

Rieske Iron–Sulfur Cluster Proteins From an Anaerobic Ammonium Oxidizer Suggest Unusual Energetics in Their Parent Rieske/Cytochrome b Complexes

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Anaerobic ammonium‐oxidizing (anammox) bacteria employ a unique, hydrazine‐based pathway to obtain energy from nitrite and ammonium. These organisms possess distinct Rieske/cytochrome b complexes whose precise role in anammox metabolism remains unclear, but which have been proposed to include the generation of NAD(P)H.
David Hauser   +4 more
wiley   +1 more source

Divergent functional isoforms drive niche specialisation for nutrient acquisition and use in rumen microbiome [PDF]

open access: yes, 2017
Many microbes in complex competitive environments share genes for acquiring and utilising nutrients, questioning whether niche specialisation exists and if so, how it is maintained.
A McKenna   +71 more
core   +3 more sources

Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism [PDF]

open access: yes, 2017
Background: Microbes, plants, and fungi synthesize an enormous number of metabolites exhibiting rich chemical diversity. For a high-level classification, metabolism is subdivided into primary (PM) and secondary (SM) metabolism.
Heizinger, Leonhard   +3 more
core   +4 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

open access: yesThe Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos   +3 more
wiley   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

open access: yesThe FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola   +11 more
wiley   +1 more source

Chemogenomics of pyridoxal 5′-phosphate dependent enzymes [PDF]

open access: yes, 2011
Pyridoxal 5'-phosphate (PLP) dependent enzymes comprise a large family that plays key roles in amino acid metabolism and are acquiring an increasing interest as drug targets.
Alessandro Paiardini   +5 more
core   +1 more source

Root tip excision‐induced exodermis lignification impacts lateral root emergence in Brachypodium distachyon

open access: yesNew Phytologist, EarlyView.
Summary The mechanisms controlling lateral root emergence in monocots, particularly the role of the exodermis, are poorly understood. We investigated how natural variation in the Brachypodium distachyon stress response shapes root system architecture by modulating cell wall dynamics.
Kevin Bellande   +8 more
wiley   +1 more source

Generation and Analysis of Expressed Sequence Tags from Olea europaea L. [PDF]

open access: yes, 2010
Olive (Olea europaea L.) is an important source of edible oil which was originated in Near-East region. In this study, two cDNA libraries were constructed from young olive leaves and immature olive fruits for generation of ESTs to discover the novel ...
Kucukural, Alper   +12 more
core   +5 more sources

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source

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