Results 101 to 110 of about 5,693 (184)

Functional analysis of the DXDDTA motif in squalene-hopene cyclase by site-directed mutagenesis experiments: initiation site of the polycyclization reaction and stabilization site of the carbocation intermediate of the initially cyclized A-ring. [PDF]

, 1999
In order to clarify the function of the DXDDTA motif in squalene-hopene cyclase and to identify the acidic amino acid residues crucial for the catalysis, site-directed mutagenesis experiments were carried out.
4375, 4376, Hoshino, Tsutomu, Sato, Tsutomu   +3 more
core   +1 more source

Identification of Putative Genes Involved in Limonoids Biosynthesis in Citrus by Comparative Transcriptomic Analysis

Frontiers in Plant Science, 2017
Limonoids produced by citrus are a group of highly bioactive secondary metabolites which provide health benefits for humans. Currently there is a lack of information derived from research on the genetic mechanisms controlling the biosynthesis of ...
Fusheng Wang, Fusheng Wang, Fusheng Wang, Mei Wang, Xiaona Liu, Yuanyuan Xu, Shiping Zhu, Shiping Zhu, Wanxia Shen, Wanxia Shen, Xiaochun Zhao, Xiaochun Zhao   +11 more
doaj   +1 more source

Purification of 2,3-oxidosqualene: cycloartenol cyclase from seedlings.

Chemical and Pharmaceutical Bulletin, 1988
2, 3-Oxidosqualene: cycloartenol cyclase (E.C.5.4.99.8) is a membrane bound enzyme prevalent in the plant kingdom.It acts as a key enzyme in phytosterol biosynthesis.Cycloartenol cyclase was purified from pea seedlings in six steps as a soluble and homogeneous enzyme. The purified enzyme showed a single band in sodium dodecylsulphate polyacrylamide gel
Ikuro Abe, Yutaka Ebizuka, Ushio Sankawa
openaire   +2 more sources

Hybrid sequencing of the Gynostemma pentaphyllum transcriptome provides new insights into gypenoside biosynthesis

BMC Genomics, 2019
Background Gypenosides are a group of triterpene saponins from Gynostemma pentaphyllum that are the same as or very similar to ginsenosides from the Panax species.
Tongtong Liang, Liqiu Zou, Sijie Sun, Xuejun Kuang, Jianhe Wei, Lizhi Wang, Ying Li, Chao Sun   +7 more
doaj   +1 more source

Molecular Cloning of cDNA Encoding Rat 2,3-Oxidosqualene: Lanosterol Cyclase.

Biological and Pharmaceutical Bulletin, 1995
A cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase, the enzyme responsible for the complex cyclization/rearrangement step in sterol biosynthesis, was cloned by extensive application of PCRs. Oligonucleotide primers were designed in sense and anti-sense directions corresponding to internal peptide sequences of purified enzyme.
M, Kusano, M, Shibuya, U, Sankawa, Y, Ebizuka   +3 more
openaire   +3 more sources

Genomic insights into ecological adaptation of oaks revealed by phylogenomic analysis of multiple species

Plant Diversity
Understanding the ecological adaptation of tree species can not only reveal the evolutionary potential but also benefit biodiversity conservation under global climate change.
Tian-Rui Wang, Xin Ning, Si-Si Zheng, Yu Li, Zi-Jia Lu, Hong-Hu Meng, Bin-Jie Ge, Gregor Kozlowski, Meng-Xiao Yan, Yi-Gang Song   +9 more
doaj   +1 more source

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols.

Journal of Lipid Research, 1990
Treatment of rat intestinal epithelial cell cultures with the oxidosqualene cyclase inhibitor, 3 beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one (U18666A), resulted in an accumulation of squalene 2,3:22,23-dioxide (SDO).
S R Panini, R C Sexton, A K Gupta, E J Parish, S Chitrakorn, H Rudney   +5 more
doaj   +1 more source

Identification of an Oxidosqualene Cyclase Gene Involved in Steroidal Triterpenoid Biosynthesis in Cordyceps farinosa. [PDF]

Genes (Basel), 2021
An GH, Han JG, Park HS, Sung GH, Kim OT.
europepmc   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

Regulation of dolichol-linked glycosylation [PDF]

, 2018
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNAc2Man9Glc3 on the polyprenol carrier dolichyl-pyrophosphate is compromised.
Welti, Michael
core