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Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant Hoodia gordonii. [PDF]

Plants (Basel)
Parveen I, Wang M, Lee J, Zhao J, Zhu Y, Chittiboyina AG, Khan IA, Pan Z.   +7 more
europepmc   +1 more source

Syntheses of sulfur-substituted 2,3-oxidosqualene analogs as inhibitors of 2,3-oxidosqualene-lanosterol cyclase

, 1995
openaire   +1 more source

Synthesis of inhibitors of 2,3-oxidosqualene-lanosterol cyclase

, 1992
openaire   +1 more source

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29-Methylidene-2,3-oxidosqualene: a potent mechanism-based inactivator of oxidosqualene cyclase

Journal of the American Chemical Society, 1991
Two pairs of isomers (18Z)- (8), (18E)-29-methylidene-2,3-oxidohexanorsqualene (21), and (18Z)- (31), (18E)-29-methylidene-2,3-oxidosqualene (34), have been obtained in a fully stereospecific manner, as inhibitors of rat and yeast oxidosqualene cyclase.
Xiao Yi Xiao, Glenn D. Prestwich
  +8 more sources

Inhibition of 2,3-oxidosqualene cyclases

Biochemistry, 1992
Monocyclic and tricyclic compounds possessing a nitrogen atom situated at a position corresponding to the carbenium ion of high energy intermediates or transition states involved during cyclization of 2,3-oxidosqualene to tetra- and pentacyclic triterpenes have been synthesized.
M, Taton, P, Benveniste, A, Rahier, W S, Johnson, H T, Liu, A R, Sudhakar   +5 more
openaire   +2 more sources

Oxidosqualene Cyclase Inhibitors as Antimicrobial Agents

Journal of Medicinal Chemistry, 2003
Small-molecule oxidosqualene cyclase (OSC) inhibitors were found to be effective in assays against cloned OSC-like enzymes from human pathogens. A combinatorial library was prepared and used to identify lead compounds that inhibit the growth of Trypanosoma cruzi, Leishmania mexicana amazonensis, and Pneumocystis carinii in culture.
Jerald C, Hinshaw, Dae-Yeon, Suh, Philippe, Garnier, Frederick S, Buckner, Richard T, Eastman, Seiichi P T, Matsuda, Bridget M, Joubert, Isabelle, Coppens, Keith A, Joiner, Salim, Merali, Theodore E, Nash, Glenn D, Prestwich   +11 more
openaire   +2 more sources