Results 171 to 180 of about 5,693 (184)

Inhibition of 2,3-oxidosqualene cyclase by N-alkylpiperidines

Bioorganic & Medicinal Chemistry Letters, 1993
A series of N-alkylpiperidines (3)–(6), truncated A-ring analogs of the azadecalins (2) were synthesized, to further elucidate the structural requirements of OSC inhibition. From the structure-activity data obtained with the “clipped” A-ring analogs (3) and piperidines (4)–(6), important interactions between these inhibitors and oxidosqualene cyclase ...
M.Woods Wannamaker, Philip P. Waid, William R. Moore, Gerald L. Schatzman, William A. Van Sickle, Pamela K. Wilson   +5 more
openaire   +1 more source

Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene‐hopene cyclases

Lipids, 2003
AbstractVarious (1E,3E)‐ and (1Z,3E)‐conjugated methylthio derivatives of oxidosqualene (OS) and conjugated and non‐conjugated phenylthio derivatives of OS were obtained. These compounds, designed as inhibitors of pig liver and Saccharomyces cerevisiae 2,3‐oxidosqualene‐lanosterol cyclases (OSC) (EC 5.4.99.7) and of Alicyclobacillus acidocaldarius ...
ROCCO, Flavio, OLIARO BOSSO, Simonetta, VIOLA, Franca Cecilia, MILLA, Paola, ROMA G., GROSSI, Giorgio, CERUTI, Maurizio   +6 more
openaire   +4 more sources

2,3‐oxidosqualene cyclase: From azasqualenes to new site‐directed inhibitors

Lipids, 1995
Abstract2,3‐Oxidosqualene cyclases (OSC) are enzymes which convert 2,3‐oxidosqualene (OS) into polycyclic triterpenoids such as lanosterol, cycloartenol, and α‐and β‐amyrin. Our interest in the study of OSC is the development of new OSC inhibitors for potential use as hypocholesterolemic, antifungal, or phytotoxic drugs.
CATTEL, Luigi, CERUTI, Maurizio, BALLIANO, Gianni, VIOLA, Franca Cecilia, GROSA, Giorgio, ROCCO, Flavio, BRUSA, Paola   +6 more
openaire   +3 more sources

Action of 2,3-oxidosqualene lanosterol cyclase on 15'-nor-18,19-dihydro-2,3-oxidosqualene

Journal of the American Chemical Society, 1982
Eugene E. Van Tamelen, Eric J. Leopold, Stuart A. Marson, Hans R. Waespe   +3 more
openaire   +1 more source

Oxidosqualene Cyclase

RCSB Protein Data Bank, 2007
openaire   +1 more source

2,3-Oxidosqualene Cyclase and Squalene Epoxidase

1992
CATTEL, Luigi, CERUTI, Maurizio
openaire   +2 more sources

2,3- Oxidosqualene cycloartenol cyclasefrom Ochromonas malhamensis

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
H H, Rees, L J, Goad, T W, Goodwin
openaire   +2 more sources

Conversion of 6-demethyl-2,3-oxidosqualene to 19-norlanosterol by 3,3-oxidosqualene--sterol cyclase

Journal of the American Chemical Society, 1971
Elias J. Corey, Alain Krief, Hisashi Yamamoto   +2 more
openaire   +1 more source

Subcellular localization of yeast oxidosqualene cyclase and other eukaryotic oxidosqualene cyclases expressed in yeast

2002
MILLA, Paola, VIOLA, Franca Cecilia, OLIARO BOSSO, Simonetta, CATTEL, Luigi, Matsuda S, Athenstaedt K, Daum G, BALLIANO, Gianni   +7 more
openaire   +1 more source

Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents

Biochemical Society Transactions, 1990
S, Jolidon, A M, Polak, P, Guerry, P G, Hartman   +3 more
openaire   +2 more sources