2,3-Oxidosqualene cyclase protects liver cells from the injury of intermittent hypoxia by regulating lipid metabolism. [PDF]
Sleep Breath, 2015 Zhen YQ +7 more
europepmc +2 more sources
Synthesis of the oxysterol, 24(
Lipids in Health and Disease, 2007 Aim The effects of 24(S),25-epoxycholesterol (24,25EC) on aspects of cholesterol homeostasis is well-documented. When added to cells, 24,25EC decreases cholesterol synthesis and up-regulates cholesterol efflux genes, including ABCA1. Synthesis of 24,25EC
Brown Andrew J +2 more
doaj +6 more sources
Genome-Wide Identification and Characterization of OSC Gene Family in Gynostemma pentaphyllum (Cucurbitaceae) [PDF]
LifeGynostemma pentaphyllum is a traditional Chinese medicinal plant of considerable application value and commercial potential, primarily due to its production of various bioactive compounds, particularly dammarane-type triterpenoid saponins that are ...
Xiao Zhang +4 more
doaj +2 more sources
Synthesis of arborane triterpenols by a bacterial oxidosqualene cyclase. [PDF]
Proc Natl Acad Sci U S A, 2017 SignificancePolycyclic lipids produced by bacteria and eukaryotes can be preserved in sedimentary rocks for millions of years. These ancient lipids can function as “molecular fossils” or biomarkers that can inform us about the types of organisms and environments on early Earth. However, proper interpretation of these biomarkers requires a comprehensive
Banta AB +4 more
europepmc +4 more sources
Functional characterization of triterpene synthases in Cibotium barometz
Synthetic and Systems Biotechnology, 2023 Cibotium barometz (Linn.) J. Sm., a tree fern in the Dicksoniaceae family, is an economically important industrial exported plant in China and widely used in Traditional Chinese Medicine. C.
Zhongju Ji +9 more
doaj +1 more source
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors [PDF]
European Journal of Medicinal Chemistry, 2016 The cyclization of oxidosqualene to lanosterol, catalyzed by the enzyme oxidosqualene cyclase (OSC), goes through a number of carbocationic high energy intermediates (HEI), and mimicking these intermediates is a promising approach for the development of OSC inhibitors. 3-Arylpiperidines (or tetrahydropyridines) were designed as steroidomimetic rings A +
Balliano, Gianni +2 more
core +3 more sources
Heliyon, 2023 Talinum paniculatum or Javanese ginseng in Indonesia is a plant widely used as a traditional medicine. The genus Talinum produces oleanane-type saponins, such as talinumoside I.
Ika Qurrotul Afifah +2 more
doaj +1 more source
Squalene cyclase and oxidosqualene cyclase from a fern [PDF]
FEBS Letters, 2007 Ferns are the most primitive vascular plants. The phytosterols of ferns are the same as those of higher plants, but they produce characteristic triterpenes. The most distinct feature is the lack of oxygen functionality at C‐3, suggesting that the triterpenes of ferns may be biosynthesized by direct cyclization of squalene.
Shinozaki, Junichi +3 more
openaire +2 more sources
The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis. [PDF]
PLoS ONE, 2017 Cyclic triterpenes constitute one of the most diverse groups of plant natural products. Besides the intriguing biochemistry of their biosynthetic pathways, plant triterpenes exhibit versatile bioactivities, including antimicrobial effects against plant ...
Anita Loeschcke +13 more
doaj +1 more source
Divergent evolution of oxidosqualene cyclases in plants [PDF]
New Phytologist, 2011 Triterpenes are one of the largest classes of plant metabolites and have important functions. A diverse array of triterpenoid skeletons are synthesized via the isoprenoid pathway by enzymatic cyclization of 2,3-oxidosqualene. The genomes of the lower plants Chlamydomonas reinhardtii and moss (Physcomitrella patens) contain just one oxidosqualene ...
Zheyong, Xue +8 more
openaire +2 more sources