Results 41 to 50 of about 5,693 (184)

Overexpression of TwSQS, TwSE, and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells

Frontiers in Plant Science, 2022
Squalene synthase (SQS), squalene epoxidase (SE), and oxidosqualene cyclase (OSC) are encoding enzymes in downstream biosynthetic pathway of triterpenoid in plants, but the relationship between three genes and celastrol accumulation in Tripterygium ...
Yadi Song, Yadi Song, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Xiujuan Wang, Tianyuan Hu, Yuru Tong, Luqi Huang, Wei Gao, Wei Gao   +10 more
doaj   +1 more source

Fermentation and purification strategies for the production of betulinic acid and its lupane-type precursors in Saccharomyces cerevisiae [PDF]

, 2017
Microbial production of plant derived, biologically active compounds has the potential to provide economic and ecologic alternatives to existing low productive, plant-based processes. Current production of the pharmacologically active cyclic triterpenoid
Arnezeder, Bergs, Blank, Chen, Cheng, Co, Dai, del Castillo Agudo, Dzubak, Farrugia, Follegatti-Romero, Fukushima, Gruchattka, Huang, Jäger, Jäger, Kirby, Kratzer, Kuo, Lang, Li, Li, Maury, Moses, O'Connell, Perrone, Polakowski, Potze, Ressmann, Salmon, Sandoval, Segura, Shang, Steyer, Tan, Tang, Teixeira, Tippmann, van den Berg, van Hoek, Verstrepen, Westfall, Wick, Willis, Wriessnegger, Zangar, Zhang, Zhou, Zuco   +48 more
core   +1 more source

Oxidosqualene Cyclases from Cell Suspension Cultures of Betula platyphylla var. japonica: Molecular Evolution of Oxidosqualene Cyclases in Higher Plants

Biological and Pharmaceutical Bulletin, 2003
Betula platyphylla var. japonica is a rich source of triterpenoid as it contains dammarane type triterpenes in the leaves, and lupane type and oleanane type triterpenes in the bark. Four oxidosqualene cyclase cDNAs (BPX, BPX2, BPW and BPY) were cloned by homology based PCR methods from cell suspension cultures of B. platyphylla var. japonica.
Hong, Zhang, Masaaki, Shibuya, Shinso, Yokota, Yutaka, Ebizuka   +3 more
openaire   +3 more sources

Engineering The Unicellular Alga Phaeodactylum tricornutum For High-Value Plant Triterpenoid Production [PDF]

, 2018
Plant triterpenoids constitute a diverse class of organic compounds that play a major role in development, plant defense and environmental interaction. Several triterpenes have demonstrated potential as pharmaceuticals.
Allen, MJ, Beacham, TA, D'Adamo, S, Landels, A, Lowe, G, Matthijs, M, Schiano di Visconte, G, Spicer, A, Szaub-Newton, J   +8 more
core   +2 more sources

Full-length transcriptome, proteomics and metabolite analysis reveal candidate genes involved triterpenoid saponin biosynthesis in Dipsacus asperoides

Frontiers in Plant Science, 2023
Dipsacus asperoides is a traditional medicinal herb widely used in inflammation and fracture in Asia. Triterpenoid saponins from D. asperoides are the main composition with pharmacological activity.
Jie Pan, Jie Pan, Chaokang Huang, Chaokang Huang, Weilin Yao, Weilin Yao, Tengfei Niu, Tengfei Niu, Xiaolin Yang, Xiaolin Yang, Xiaolin Yang, Rufeng Wang, Rufeng Wang, Rufeng Wang, Rufeng Wang   +14 more
doaj   +1 more source

Triterpenoid biosynthesis and engineering in plants

Frontiers in Plant Science, 2011
Triterpenoid saponins are a diverse group of natural products in plants and are considered defensive compounds against pathogenic microbes and herbivores.
Satoru eSawai, Kazuki eSaito, Kazuki eSaito   +2 more
doaj   +1 more source

Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. [PDF]

PLoS ONE, 2016
Lactobacillus acidophilus species are well-known probiotics with the beneficial activity of regulating cholesterol levels. In this study, we showed that L. acidophilus K301 reduced the level of cholesterol through reverse transport in macrophages.
Yi-Fan Hong, Hangeun Kim, Hye Sun Kim, Woo Jung Park, Joo-Yun Kim, Dae Kyun Chung   +5 more
doaj   +1 more source

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML [PDF]

, 2013
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently,
Armstrong, Scott A., Arreba-Tutusaus, Patricia, Bullinger, Lars, Döhner, Konstanze, Fischer, Thomas, Gaebel, Julia, Heidel, Florian H., Hirt, Carsten, Lane, Steven W., Niederwieser, Dietger, Vasioukhin, Valera, Wang, Zhu   +11 more
core   +2 more sources

Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae [PDF]

Lipids, 2005
AbstractRecently, a number of inhibitors of the enzyme oxidosqualene cyclase (OSC; EC 5.4.99.7), a key enzyme in sterol biosynthesis, were shown to inhibit in mammalian cells the multiplication of Trypanosoma cruzi, the parasite agent of Chagas’ disease. The gene coding for the OSC of T.
Balliano, Gianni, Ceruti, Maurizio, Milla, Paola, Oliaro Bosso, Simonetta, Rocco, Flavio, Viola, Franca Cecilia   +5 more
core   +4 more sources

Tuscan Varieties of Sweet Cherry Are Rich Sources of Ursolic and Oleanolic Acid: Protein Modeling Coupled to Targeted Gene Expression and Metabolite Analyses

Molecules, 2019
The potential of six ancient Tuscan sweet cherry (Prunus avium L.) varieties as a source of health-promoting pentacyclic triterpenes is here evaluated by means of a targeted gene expression and metabolite analysis. By using a sequence homology criterion,
Roberto Berni, Mubasher Zahir Hoque, Sylvain Legay, Giampiero Cai, Khawar Sohail Siddiqui, Jean-Francois Hausman, Christelle M. Andre, Gea Guerriero   +7 more
doaj   +1 more source