Results 61 to 70 of about 5,693 (184)

Evaluating the Evolutionary Origins of Unexpected Character Distributions within the Bacterial Planctomycetes-Verrucomicrobia-Chlamydiae Superphylum [PDF]

open access: yes, 2012
Recently, several characters that are absent from most bacteria, but which are found in many eukaryotes or archaea, have been identified within the bacterial Planctomycetes-Verrucomicrobia-Chlamydiae (PVC) superphylum.
A. Budd, D. P. Devos
core   +1 more source

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

open access: yesAdvanced Science, Volume 12, Issue 44, November 27, 2025.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao   +11 more
wiley   +1 more source

Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms

open access: yesMolecules, 2018
Triterpenes are interesting compounds because they play an important role in cell homeostasis and a wide variety exhibiting defense functions is produced by plant secondary metabolism.
Thaís B. Alves   +4 more
doaj   +1 more source

Characterization of a Pentacyclic Triterpene Acetyltransferase Involved in the Biosynthesis of Taraxasterol and ψ-Taraxasterol Acetates in Lettuce

open access: yesFrontiers in Plant Science, 2022
Triterpenoids exist in a free state and/or in conjugated states, such as triterpene glycosides (saponins) or triterpene esters. There is no information on the enzyme participating in the production of triterpene esters from free triterpenes.
Han Suk Choi   +3 more
doaj   +1 more source

PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK [PDF]

open access: yes, 2016
This work was supported by Grant No. 81201779 (Hua Xiong) from the National Natural Science Youth Foundation; Grant No. 81502118 (Yanmei Zou) from the National Natural Science Youth Foundation; Grant No.
Duan, Qiuhong   +15 more
core   +2 more sources

Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa

open access: yesPlant Biotechnology Journal, Volume 23, Issue 10, Page 4214-4227, October 2025.
Summary Saponins constitute a class of characteristic compounds within quinoa grains. In this study, metabolomic analysis identified 20 triterpene saponins, the majority of which were exclusively localized within the pericarp. Furthermore, three crucial glycosyltransferases were identified in quinoa.
Yiming Zhang   +14 more
wiley   +1 more source

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo

open access: yesJournal of Lipid Research, 1997
BIBB 515 (1-(4-chlorobenzoyl)-4-((4-(2-oxazolin-2-yl) benzylidene))piperidine) is a potent and selective inhibitor of 2,3-oxidosqualene cyclase (OSC) [EC 5.4.99.7].
B Eisele   +4 more
doaj   +1 more source

Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. [PDF]

open access: yesPLoS ONE, 2014
The plant sterol pathway exhibits a major biosynthetic difference as compared with that of metazoans. The committed sterol precursor is the pentacyclic cycloartenol (9β,19-cyclolanost-24-en-3β-ol) and not lanosterol (lanosta-8,24-dien-3β-ol), as it was ...
Elisabet Gas-Pascual   +3 more
doaj   +1 more source

Production of Helvolic Acid in Metarhizium Contributes to Fungal Infection of Insects by Bacteriostatic Inhibition of the Host Cuticular Microbiomes

open access: yesMicrobiology Spectrum, 2022
The nortriterpenoid helvolic acid (HA) has potent antibiotic activities and can be produced by different fungi, yet HA function remains elusive. Here, we report the chemical biology of HA production in the insect pathogen Metarhizium robertsii.
Yanlei Sun   +4 more
doaj   +1 more source

Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. [PDF]

open access: yes, 2002
Oxidosqualene cyclase of the yeast encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of sterol biosynthesis. In a previous study (Athenstaedt, K., Zweytick, D., Jandrositz, A, Kohlwein, S. D., and Daum, G. (1999) J.
Franca Viola   +6 more
core   +2 more sources

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