Results 71 to 80 of about 5,693 (184)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, Volume 19, Issue 8, Page 2292-2309, August 2025.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Modifications of Prenyl Side Chains in Natural Product Biosynthesis

Angewandte Chemie, Volume 136, Issue 52, December 20, 2024.
This review summarizes the unique modifications of prenyl side chains involved in natural product biosynthesis, including epoxidation, dehydrogenation, oxidation of methyl groups to carboxyl groups, C−C bond cleavage and oxidative cyclization. Abstract In recent years, there has been a growing interest in understanding the enzymatic machinery ...
Huibin Wang, Yi Yang, Ikuro Abe
wiley   +2 more sources

Integrated Metabolomics and Transcriptomics Analysis Reveals New Insights into Triterpene Biosynthesis in Rosa rugosa

Plants
Rosa rugosa is highly regarded for its aesthetic and therapeutic qualities. In particular, R. rugosa’s flowers are known to produce essential oils containing a mixture of volatile terpenes, phenylpropanoids, and other compounds.
Guo Wei, Yang Xu, Pengqing Wang, Hammad Hussain, Yudie Chen, Yuqing Shi, Kaikai Zhu, Mengjuan Bai, Yong Xu, Jianwen Wang, Liguo Feng   +10 more
doaj   +1 more source

De novo genome assembly and annotation of rice sheath rot fungus Sarocladium oryzae reveals genes involved in Helvolic acid and Cerulenin biosynthesis pathways [PDF]

, 2016
Morphology of Saro-13 isolate used for whole genome sequencing.
Channappa Mahadevaiah, H. B. Mahesh, Mothukapalli Krishnareddy Prasannakumar, Shailaja Hittalmani   +3 more
core   +9 more sources

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape‐enhancing saponins

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3068-3082, August 2025.
Summary The limited cytosolic delivery of DNA and protein‐based therapeutics due to endosomal entrapment reduces drug efficacy, increasing treatment costs and possible side effects in human and veterinary medicine as a consequence of higher administered dosages.
Elia Lacchini, Tongtong Qu, Tessa Moses, Alexander N. Volkov, Alain Goossens   +4 more
wiley   +1 more source

Biosynthesis and functions of triterpenoids in cereals

Journal of Advanced Research
Background: Triterpenoids are versatile secondary metabolites with a diverse array of physiological activities, possessing valuable pharmacological effects and influencing the growth and development of plants.
Jiaojiao Lu, Shan Yan, Zheyong Xue
doaj   +1 more source

A Review of Bioactive Components and Pharmacological Effects of Ganoderma lucidum

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
The active substances and medicinal effects of the medicinal mushroom Ganoderma lucidum were reviewed. ABSTRACT Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promoting physical well‐being, enhancing stamina, and boosting vitality.
Sizhu Ren, Hua Liu, Qing Sang, Mengqi Lu, Qing Gao, Wenjie Chen   +5 more
wiley   +1 more source

Biochemical research elucidating metabolic pathways in Pneumocystis*

Parasite, 2010
Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
doaj   +1 more source

Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor

Journal of Lipid Research, 2004
Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage within a few weeks of treatment.
Richard J. Cenedella, Robert Jacob, Douglas Borchman, Daxin Tang, Amanda R. Neely, Abbas Samadi, R. Preston Mason, Patricia Sexton   +7 more
doaj   +1 more source

Umbelliferone aminoalkyl derivatives as inhibitors of human oxidosqualene-lanosterol cyclase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009
Human and murine lanosterol synthases (EC 5.4.99.7) were studied as targets of a series of umbelliferone aminoalkyl derivatives previously tested as inhibitors of oxidosqualene cyclases from other eukaryotes. Tests were carried out on cell cultures of human keratinocytes and mouse 3T3 fibroblasts incubated with radiolabeled acetate, and on homogenates ...
OLIARO BOSSO, Simonetta, TARAMINO, Silvia, VIOLA, Franca Cecilia, TAGLIAPIETRA, Silvia Maria, ERMONDI, Giuseppe, CRAVOTTO, Giancarlo, BALLIANO, Gianni   +6 more
openaire   +3 more sources