Results 81 to 90 of about 5,693 (184)

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, Volume 61, Issue 3, Page 512-528, June 2025.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

Potent Anti- Trypanosoma cruzi Activities of Oxidosqualene Cyclase Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT Trypanosoma cruzi is the protozoan agent that causes Chagas' disease, a major health problem in Latin America. Better drugs are needed to treat infected individuals. The sterol biosynthesis pathway is a potentially excellent target for drug therapy against T. cruzi .
F S, Buckner, J H, Griffin, A J, Wilson, W C, Van Voorhis   +3 more
openaire   +2 more sources

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Enhancing Crop Nutrition in Arid and Semiarid Regions of Africa Through Genome Editing Using CRISPR/Cas

Food and Energy Security, Volume 14, Issue 3, May/June 2025.
ABSTRACT Food insecurity is a pressing issue in Africa, aggravated by escalating drought, jeopardizing the region's ability to meet nutritional requirements for human health. In arid and semiarid regions, crop yield is severely affected by drought and salinity.
Erick Amombo, Rita H. Mumm, Abdelaziz Nilahyane, Abdelaziz Hirich, Mohamed Hijri, Valentine Otang Ntui   +5 more
wiley   +1 more source

Navigating the challenges of engineering composite specialized metabolite pathways in plants

The Plant Journal, Volume 121, Issue 6, March 2025.
SUMMARY Plants are a valuable source of diverse specialized metabolites with numerous applications. However, these compounds are often produced in limited quantities, particularly under unfavorable ecological conditions. To achieve sufficient levels of target metabolites, alternative strategies such as pathway engineering in heterologous systems like ...
Sachin A. Gharat, Vaijayanti A. Tamhane, Ashok P. Giri, Asaph Aharoni   +3 more
wiley   +1 more source

Multi-tissue transcriptome analysis using hybrid-sequencing reveals potential genes and biological pathways associated with azadirachtin A biosynthesis in neem (azadirachta indica)

BMC Genomics, 2020
Background Azadirachtin A is a triterpenoid from neem tree exhibiting excellent activities against over 600 insect species in agriculture. The production of azadirachtin A depends on extraction from neem tissues, which is not an eco-friendly and ...
Huiyan Wang, Ning Wang, Yixin Huo
doaj   +1 more source

Kinetic studies on the function of all the conserved tryptophans involved inside and outside the QW motifs of squalene-hopene cyclase: stabilizing effect of the protein structure against thermal denaturation. [PDF]

, 1999
Site-directed mutagenesis experiments were carried out to identify the responsibility of the eight QW motifs for the reaction catalyzed by squalene-hopene cyclase (SHC).
4371, 4372, Hoshino, Tsutomu, Sato, Tsutomu   +3 more
core   +1 more source

The cis‐prenyltransferase protein family in Taraxacum koksaghyz

The Plant Journal, Volume 121, Issue 3, February 2025.
Significance Statement The novelty of this work lies in the comprehensive description of cis‐prenyl transferases in the rubber‐producing plant Taraxacum koksaghyz. This provides valuable insights for breeding and rational protein design in heterologous systems.
Boje Müller, Eva Niephaus, Wolfgang Eisenreich, Jan Niklas Bröker, Richard M. Twyman, Dirk Prüfer, Christian Schulze Gronover   +6 more
wiley   +1 more source

Aquilaria sinensis: An Upstart Resource for Cucurbitacin Production Offers Insights into the Origin of Plant Bitter (Bi) Gene Clusters

Plants
Cucurbitacins, oxygenated tetracyclic triterpenoids that are found mainly in the Cucurbitaceae family, play essential roles as defensive compounds, serving as allomones against herbivores and pathogens and as signals for insect–parasite recognition ...
Xupo Ding, Zhuo Yang, Hao Wang, Jun Zeng, Haofu Dai, Wenli Mei   +5 more
doaj   +1 more source