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Current Opinion in Hematology, 1996
Alternative oxygen carriers are being evaluated in human studies. Information from the clinical evaluation of these "blood substitutes" is not publicly available. Preclinical studies of solutions of modified cell-free hemoglobin and of perfluorocarbon emulsions have demonstrated significant toxicity.
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Alternative oxygen carriers are being evaluated in human studies. Information from the clinical evaluation of these "blood substitutes" is not publicly available. Preclinical studies of solutions of modified cell-free hemoglobin and of perfluorocarbon emulsions have demonstrated significant toxicity.
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Hemoglobin-based oxygen carriers
Current Opinion in Hematology, 2002Three types of materials have been studied as candidate blood substitutes: the perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin. Progress has been greatest with the hemoglobin-based oxygen carriers. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects.
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A hypothetical tissue oxygen carrier
Microvascular Research, 1970Abstract The relation between the respiration rate of fresh liver, kidney, or heart slices and the ambient partial pressure of oxygen follow “saturation” or Michaelis-Menten kinetics rather than those predicted if passive diffusion is the mechanism of tissue oxygen transport.
I S, Longmuir, S, Sun
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Haemoglobin-based oxygen carriers
Expert Opinion on Investigational Drugs, 2000Haemoglobin-based oxygen carriers are being developed for use in blood replacement therapies, either for perioperative haemodilution or for resuscitation from haemorrhagic blood loss. There is a high demand for these products because of risks associated with blood transfusions and pending worldwide blood shortages.
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Baillière's Clinical Anaesthesiology, 1988
Summary At present there are two credible forms of artificial oxygen carrier for intravascular use. Polymerized tensed haemoglobin solutions have very similar characteristics to red cells but are still difficult to produce in nontoxic forms. They have the advantage that they can accept a full load of oxygen by exposure to normal alveolar air.
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Summary At present there are two credible forms of artificial oxygen carrier for intravascular use. Polymerized tensed haemoglobin solutions have very similar characteristics to red cells but are still difficult to produce in nontoxic forms. They have the advantage that they can accept a full load of oxygen by exposure to normal alveolar air.
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Oxygen carriers: A selected review
Transfusion and Apheresis Science, 2006The most common and widely transplanted tissue world wide is blood, which in 2000 resulted in the transfusion of 12.5 million units of blood in the US alone [Goodnough LT, Shander A, Brecher ME. Transfusion medicine: looking to the future. Lancet 2003;361:161-9].
Mohammed S, Inayat +5 more
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Hemoglobin‐based oxygen carriers
TransfusionSee article on page 1161–1166, in this ...
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1985
The authors wish to dedicate this article to the memory of Professor Eraldo Antonini, who died of an incurable illness on 19 March 1983. It was Professor Antonini who introduced the authors to the study of oxygen-carrying proteins and inspired their scientific activity.
Maurizio Brunori +2 more
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The authors wish to dedicate this article to the memory of Professor Eraldo Antonini, who died of an incurable illness on 19 March 1983. It was Professor Antonini who introduced the authors to the study of oxygen-carrying proteins and inspired their scientific activity.
Maurizio Brunori +2 more
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Baillière's Clinical Anaesthesiology, 1997
Intravenous (i.v.) artificial oxygen carriers are intended to ensure adequate tissue oxygenation in critical anaemia (haemorrhagic shock, profound normovolaemic haemodilution). As regards their efficacy, both synthetic haemoglobin solutions and perfluorocarbon (PFC) emulsions, are suited to preserve tissue oxygenation after nearly complete blood ...
Oliver P. Habler, Konrad F.W. Messmer
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Intravenous (i.v.) artificial oxygen carriers are intended to ensure adequate tissue oxygenation in critical anaemia (haemorrhagic shock, profound normovolaemic haemodilution). As regards their efficacy, both synthetic haemoglobin solutions and perfluorocarbon (PFC) emulsions, are suited to preserve tissue oxygenation after nearly complete blood ...
Oliver P. Habler, Konrad F.W. Messmer
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Current opinion in investigational drugs (London, England : 2000), 2003
Three polyhemoglobins, formed by intermolecular cross-linking of hemoglobin molecules are in advanced phase III clinical trials and two conjugated hemoglobins, formed by cross-linking of hemoglobin molecules with soluble polymer, are also undergoing clinical trials.
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Three polyhemoglobins, formed by intermolecular cross-linking of hemoglobin molecules are in advanced phase III clinical trials and two conjugated hemoglobins, formed by cross-linking of hemoglobin molecules with soluble polymer, are also undergoing clinical trials.
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