Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help? [PDF]
Intense efforts have been made by both industry and academia over the last three decades to produce viable hemoglobin (Hb)-based oxygen carriers (HBOCs), also known as “blood substitutes”.
Abdu I. Alayash
doaj +4 more sources
Nanobiotechnology and blood substitutes
Sir, Nanobiotechnology is the assembling of biological molecules into 1–100 nm dimensions. These dimensions can be the diameter of nanodimension artificial cells or particles; membranes with nanodimension thickness or nanotubules with nanodimension diameter.[1] Since red blood cell (RBC) membrane includes blood group antigens, typing and matching ...
Saini Rajiv +2 more
doaj +4 more sources
Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes [PDF]
Microcirculatory preservation is essential for patient recovery from hemorrhagic shock. In hemorrhagic shock, microcirculatory flow and pressure are greatly reduced, creating an oxygen debt that may eventually become irreversible.
Carlos Munoz +5 more
doaj +2 more sources
Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility [PDF]
The 21st century is challenging for human beings. Increased population growth, population aging, generation of new infectious agents, and natural disasters are some threatening factors for the current state of blood transfusion.
Samira Moradi +2 more
doaj +2 more sources
Blood Substitutes Used in Dentistry and OMFS: Systematic Review
Perioperative blood loss during dental and oral and maxillofacial surgical (OMFS) procedures often necessitates red blood cell (RBC) transfusion. However, associated risks, cost, and supply limitations have prompted the exploration of alternatives and ...
Rajshree Borah +6 more
doaj +2 more sources
Blood substitutes: Basic science, translational studies and clinical trials [PDF]
Jonathan S. Jahr
doaj +2 more sources
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis [PDF]
Background Hypertension is a major risk factor for cardiovascular disease. Salt substitutes may reduce sodium intake while maintaining palatability, but comparative effects across formulations remain uncertain.
Honghao Lai +13 more
doaj +2 more sources
Blood substitutes: why haven’t we been more successful? [PDF]
Abdu Alayash
exaly +2 more sources
Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes [PDF]
Pascal Jonkheijm
exaly +2 more sources

