Nanobiotechnology and blood substitutes [PDF]
Asian Journal of Transfusion Science, 2011 Sir, Nanobiotechnology is the assembling of biological molecules into 1–100 nm dimensions. These dimensions can be the diameter of nanodimension artificial cells or particles; membranes with nanodimension thickness or nanotubules with nanodimension diameter.[1] Since red blood cell (RBC) membrane includes blood group antigens, typing and matching ...
Saini Rajiv +2 more
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Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility [PDF]
Clinical Medicine Insights: Blood Disorders, 2016 The 21st century is challenging for human beings. Increased population growth, population aging, generation of new infectious agents, and natural disasters are some threatening factors for the current state of blood transfusion.
Samira Moradi +2 more
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Synthetic oxygen carriers as substitutes of red blood cells for blood transfusion [PDF]
RSC AdvancesThe search for an efficacious blood substitute has remained a persistent challenge for more than a century. Despite extensive efforts to develop synthetic oxygen carriers, no broadly approved alternative to human blood has yet been realized.
Yinghong Shi +7 more
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Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes [PDF]
Frontiers in Medicine, 2020 Microcirculatory preservation is essential for patient recovery from hemorrhagic shock. In hemorrhagic shock, microcirculatory flow and pressure are greatly reduced, creating an oxygen debt that may eventually become irreversible.
Carlos Munoz +5 more
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Blood Substitutes Used in Dentistry and OMFS: Systematic Review [PDF]
Journal of Pharmacy and Bioallied SciencesPerioperative blood loss during dental and oral and maxillofacial surgical (OMFS) procedures often necessitates red blood cell (RBC) transfusion. However, associated risks, cost, and supply limitations have prompted the exploration of alternatives and ...
Rajshree Borah +6 more
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Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help? [PDF]
Biomolecules, 2017 Intense efforts have been made by both industry and academia over the last three decades to produce viable hemoglobin (Hb)-based oxygen carriers (HBOCs), also known as “blood substitutes”.
Abdu I. Alayash
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Blood substitutes: Basic science, translational studies and clinical trials [PDF]
Frontiers in Medical Technology, 2022 Jonathan S. Jahr
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Blood substitutes: why haven't we been more successful? [PDF]
Trends Biotechnol, 2014 Alayash AI.
europepmc +2 more sources
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis [PDF]
BMC MedicineBackground Hypertension is a major risk factor for cardiovascular disease. Salt substitutes may reduce sodium intake while maintaining palatability, but comparative effects across formulations remain uncertain.
Honghao Lai +13 more
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Pharmaceutics, 2021 Hemoglobin (Hb)-based oxygen carriers (HBOCs) display the excellent oxygen-carrying properties of red blood cells, while overcoming some of the limitations of donor blood.
Clara Coll-Satue +3 more
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