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Kinetics of oxygen uncoupling of a copper based oxygen carrier

Applied Energy, 2016
Here, an oxygen carrier consisting of 60wt% CuO supported on a mixture of Al2O3 and CaO (23wt% and 17wt% respectively) was synthesised by wet-mixing powdered CuO, Al(OH)3 and Ca(OH)2, followed by calcination at 1000°C.
Wenting Hu, Felix Donat, Stuart A Scott   +2 more
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Hemoglobin-based oxygen carriers

Current Opinion in Hematology, 2002
Three types of materials have been studied as candidate blood substitutes: the perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin. Progress has been greatest with the hemoglobin-based oxygen carriers. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects.
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Haemoglobin-based oxygen carriers

Expert Opinion on Investigational Drugs, 2000
Haemoglobin-based oxygen carriers are being developed for use in blood replacement therapies, either for perioperative haemodilution or for resuscitation from haemorrhagic blood loss. There is a high demand for these products because of risks associated with blood transfusions and pending worldwide blood shortages.
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Oxygen Carriers and Transfusion Medicine

Artificial Cells, Blood Substitutes, and Biotechnology, 1994
The US blood supply is once again expanding (14 million units a year) and annual estimated whole blood and red blood cell (RBC) transfusion now exceeds 12 million units. The observed increase in total transfusions and units transfused per surgical procedure may result from more aggressive therapies, an aging population, and improved access to health ...
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Facilitated Oxygen Diffusion by Oxygen Carriers

1981
Diffusion is a slow process. Oxygen has only a very limited solubility in water. Consequently, the rate of diffusion of oxygen into respiring cells limits the size of cells and limits the rate at which they can do sustained work. In those vertebrate muscles which are dedicated to sustained activity, the red muscles and red fibers in muscles of mixed ...
Jonathan B. Wittenberg, Beatrice A. Wittenberg   +1 more
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Current Status of Artificial Oxygen Carriers

Advanced Drug Delivery Reviews, 2000
Artificial oxygen carriers may be grouped into modified hemoglobin solutions and fluorocarbon emulsions. In animal experiments, both have been shown to be efficacious in improving tissue oxygenation and as substitutes for blood transfusions. Advantages and disadvantages are being discussed in this article as well as the latest steps in the clinical ...
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Hemoglobin‐based oxygen carriers

Transfusion
See article on page 1161–1166, in this ...
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Cerebral Vasoactivity and Oxygenation with Oxygen Carrier M101 in Rats

Journal of Neurotrauma, 2017
The severity of traumatic brain injury (TBI) may be reduced if oxygen can be rapidly provided to the injured brain. This study evaluated if the oxygen-carrier M101 causes vasoconstricton of pial vasculature in healthy rats (Experiment 1) and if M101 improves brain tissue oxygen (PbtO2) in rats with controlled cortical impact (CCI)-TBI (Experiment 2 ...
Paula, Moon-Massat, Saad Habib-E-Rasul, Mullah, Rania, Abutarboush, Biswajit K, Saha, Georgina, Pappas, Ashraful, Haque, Charles, Auker, Richard M, McCarron, Francoise, Arnaud, Anke, Scultetus   +9 more
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HemoCD as an Artificial Oxygen Carrier: Oxygen Binding and Autoxidation

Artificial Organs, 2009
AbstractDespite many attempts to construct completely artificial systems for carrying oxygen (O2) in aqueous solution, no successful example had been reported until quite recently except for picket fence porphinatoiron(II) embedded in liposomal membrane. We newly prepared a 1:1 complex (hemoCD) of 5,10,15,20‐tetrakis(4‐sulfonatophenyl)porphinatoiron(II)
Koji, Kano, Hiroaki, Kitagishi
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Oxygen carriers.

Current opinion in investigational drugs (London, England : 2000), 2003
Three polyhemoglobins, formed by intermolecular cross-linking of hemoglobin molecules are in advanced phase III clinical trials and two conjugated hemoglobins, formed by cross-linking of hemoglobin molecules with soluble polymer, are also undergoing clinical trials.
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