Results 41 to 50 of about 955,068 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mathematical model for predicting oxygen concentration in tilapia fish farms

Scientific Reports, 2021
The main aim of this research is to develop a mathematical model to predict the dissolved oxygen in recirculating aquaculture system. The oxygen consumption of the model through the fish respiration and nitrification and the oxygen addition of the model ...
El-Sayed Khater, Adel Bahnasawy, Hossam El-Ghobashy, Yousry Shaban, Faisal Elsheikh, Solaf Abd El-Reheem, Mohamed aboegela   +6 more
doaj   +1 more source

Oxygen Cost of Recreational Horse-Riding in Females [PDF]

, 2014
Version: as accepted for publication.BACKGROUND: The purpose of this study was to characterize the physiological demands of a riding session comprising different types of recreational horse riding in females. METHODS: Sixteen female recreational riders (
Beale, L, Church, A, Gibson, OR, Maxwell, NS, Taylor, B, Twomey, R   +5 more
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The effect of high-intensity interval training on hypertrophy, strength and oxidative capacity of active muscles in power sports athletes: a cross-sectional study

Спортивная медицина: наука и практика, 2020
Objective: the purpose of the study was to evaluate how high-intensity interval training affects strength, oxidative capacity and hypertrophy of working muscles in power sports athletes.
A. B. Miroshnikov, V. V. Volkov, A. V. Smolensky   +2 more
doaj   +1 more source

Plant respirometer enables high resolution of oxygen consumption rates [PDF]

, 1966
Plant respirometer permits high resolution of relatively small changes in the rate of oxygen consumed by plant organisms undergoing oxidative metabolism in a nonphotosynthetic state.
Foster, D. L.
core   +1 more source

Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion. [PDF]

, 2017
Under acute hypoxic conditions, the muscle oxygen uptake (mV˙O2) during exercise is reduced by the restriction in oxygen-supplied volume to the mitochondria within the peripheral tissue. This suggests the existence of a factor restricting the mV˙O2 under
Furuichi, Yasuro, Hashimoto, Takeshi, Iwase, Satoshi, Jue, Thomas, Masuda, Kazumi, Ojino, Minoru, Takakura, Hisashi, Yamada, Tatsuya   +7 more
core   +1 more source

ADENOSINE ON MYOCARDIAL OXYGEN CONSUMPTION [PDF]

British Journal of Pharmacology, 1976
A 3 min intracoronary infusion of adenosine (50 μg/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow.
G J, Gross, H F, Hardman, D C, Warltier
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source