Results 41 to 50 of about 770,573 (305)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Respiratory metabolism in Oreochromis mossambicus, Peters under different environmental conditions [PDF]

, 1994
Oxygen consumption in Oreochromis mossambicus, Peters (3-60g in weight) was measured under different stress conditions at a constant temperature of 20±1°C.
Chatterji, A., Rattan, P., Thampi, R.
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Oxygen Consumption by Postfermentation Wine Yeast Lees: Factors Affecting Its Rate and Extent under Oenological Conditions

Food Technology and Biotechnology, 2016
Postfermentation wine yeast lees show antioxidant properties based on their ability to consume dissolved oxygen. The oxygen consumption capacity of suspended yeast lees obtained after fermentations with six commercial active dry yeast strains was ...
Volker Schneider, Jonas Müller, Dominik Schmidt   +2 more
doaj   +1 more source

Oxygen Consumption Rate of Tissue Measured by a Micropolarographic Method [PDF]

The Journal of General Physiology, 1966
A new method for measuring the oxygen consumption rate of a sheet of homogeneous tissue is described. The method measures, by a Clark-type oxygen electrode without a membrane, the time for the tissue to consume all its dissolved oxygen. The electrode is applied to one surface of the tissue sheet and the other surface is sealed from the atmosphere by a ...
G H, Takahashi, I, Fatt, T K, Goldstick
openaire   +2 more sources

Effects of harmful algal blooms on fish: Insights from Prymnesium parvum [PDF]

, 2018
Blooms of the planktonic alga Prymnesium parvum pose a global threat, causing fish kills worldwide. Early studies on the exposure of fish to P. parvum indicate that toxic effects are related to gill damage.
Andersen, Nikolaj Reducha, Hansen, Per, Steffensen, John Fleng, Svendsen, Morten Thougaard   +3 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Highly Efficient Method for Measuring Oxygen Consumption Rate in Fusarium graminearum

Bio-Protocol, 2016
The filamentous ascomycete Fusarium graminearum is the causal agent of Fusarium head blight, a devastating disease of cereals with a worldwide distribution.
Daniel Gebhard, Jakob Bönnighausen, Jörg Bergemann, Wilhelm Schäfer, Jörg Bormann   +4 more
doaj   +1 more source

Catastrophic temperature of oxidation-spontaneous-combustion for bituminous coal under uniaxial stress

工程科学学报, 2021
To explore the influence of the oxidation and spontaneous combustion process of fractured coal at different burial depths under uniaxial stress, the spontaneous combustion characteristics of coal under loading was studied within the testing device of ...
Yong-liang XU, Ze-jian LIU, Yun-chuan BU, Meng-lei CHEN, Zhi-guang LÜ, Lan-yun WANG   +5 more
doaj   +1 more source