Results 51 to 60 of about 770,573 (305)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

PO2 dependence of oxygen consumption in skeletal muscle of hypertensive and normotensive rats [PDF]

, 2017
Human essential hypertension affects over 75 million people in the United States, and can lead to death due to its several serious health complications such as hypertension-related cardiovascular disease.
Shah, Habiba
core   +1 more source

Effect of selective heart rate slowing in heart failure with preserved ejection fraction [PDF]

, 2015
Background Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy.
Ashrafian, Houman, Dawson, Dana K., Dwight, Jeremy S., Francis, Jane M., Frenneaux, Michael, Mahmod, Masliza, Neubauer, Stefan, Pal, Nikhil, Rudd, Amelia, Singh, Satnam, Sivaswamy, Nadiya, Watkins, Hugh, Yavari, Arash   +12 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microcirculation and Macrocirculation in Cardiac Surgical Patients

Critical Care Research and Practice, 2012
Background. The aim of our study was to investigate the relationship between microcirculatory alterations after open cardiac surgery, macrohemodynamics, and global indices of organ perfusion. Methods.
Elli-Sophia Tripodaki, Athanasios Tasoulis, Antigoni Koliopoulou, Ioannis Vasileiadis, Leonidas Vastardis, Giorgos Giannis, Mihalis Argiriou, Christos Charitos, Serafim Nanas   +8 more
doaj   +1 more source

Metabolic Rate of Cherax Quadricarinatus [PDF]

, 2012
Temperature is the most prominent factor that influence metabolic rate of aquatic animals. In general, the increasing temperature of 10 degrees Celsius will improve metabolic rate two-fold.
Aji, L. P. (Ludi)
core  

Biocatalyst Screening with a Twist: Application of Oxygen Sensors Integrated in Microchannels for Screening Whole Cell Biocatalyst Variants [PDF]

, 2018
Selective oxidative functionalization of molecules is a highly relevant and often demanding reaction in organic chemistry. The use of biocatalysts allows the stereo- and regioselective introduction of oxygen molecules in organic compounds at milder ...
Fernandes, Ana C., Gernaey, Krist V., Halder, Julia M., Hauer, Bernhard, Krühne, Ulrich, Nestl, Bettina M.   +5 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Effects of Compression Pants on Oxygen Consumption and Heart Rate during Long-Distance Running

Biomechanics
The purpose of this study was to compare average rate of oxygen consumption (VO2), slow component of oxygen consumption (VO2 drift), heart rate (HR) and rating of perceived exertion (RPE) while wearing compression pants vs.
Andrew Craig-Jones, Daniel R. Greene, Haley L. Gilbert, Priya L. Giddens, Jonathan J. Ruiz-Ramie   +4 more
doaj   +1 more source

The effect of high-intensity interval training on hypertrophy, strength and oxidative capacity of active muscles in power sports athletes: a cross-sectional study

Спортивная медицина: наука и практика, 2020
Objective: the purpose of the study was to evaluate how high-intensity interval training affects strength, oxidative capacity and hypertrophy of working muscles in power sports athletes.
A. B. Miroshnikov, V. V. Volkov, A. V. Smolensky   +2 more
doaj   +1 more source