Results 101 to 110 of about 509,742 (296)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Different electrode modification protocols for evaluating the water-splitting properties of a P(V)-metalloporphyrin [PDF]

Journal of the Serbian Chemical Society
Water electrolysis is currently a notable research domain, having the identification of highly active, stable, and low-cost electrocatalysts as one of its most important pursuits.
Taranu Bogdan-Ovidiu
doaj   +1 more source

Chemical evolution of turbulent protoplanetary disks and the Solar nebula

, 2011
This is the second paper in a series where we study the influence of transport processes on the chemical evolution of protoplanetary disks. Our analysis is based on a flared alpha-model of the DM Tau system, coupled to a large gas-grain chemical network.
Aikawa, Aikawa, Aikawa, Aikawa, Aikawa, Andrews, Bauer, Bergin, Bergin, Bethell, Biver, Bockelée-Morvan, Boss, Bradley, Brownlee, Calvet, Cant, Cazaux, Chapillon, Crabtree, D'Alessio, d'Hendecourt, D. Semenov, D. Wiebe, Dickens, Duschl, Dutrey, Dutrey, Dutrey, Finocchi, Fogel, Fukagawa, Gail, Garrod, Glassgold, Glassgold, Glassgold, Glassgold, Gorti, Gorti, Greenberg, Greenberg, Harada, Hasegawa, Heinzeller, Henning, Hersant, Hirose, Hughes, Juhász, Jørgensen, Kalenskii, Kamp, Katz, Kim, Lahuis, Lee, Lee, Lee, Leger, Lynden-Bell, Mazzitelli, Meijerink, Najita, Najita, Pagani, Pascucci, Perez-Becker, Pierce, Pontoppidan, Pontoppidan, Pontoppidan, Prinn, Qi, Qi, Sakai, Salyk, Salyk, Sarrasin, Savin, Schräpler, Semenov, Semenov, Shakura, Shalabiea, Simon, Terada, Turner, Turner, Vasyunin, Vasyunin, Vasyunin, Wakelam, Wakelam, Walsh, Willacy, Willacy, Wolf, Wooden, Wooden, Woods, Woods, Zasowski, Öberg   +103 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Application of Oxygen Reduction Reaction, Oxygen Evolution Reaction and Hydrogen Evolution Reaction in Electrochemical Biosensing

International Journal of Electrochemical Science, 2022
Jianlin Zhou, Ping Qin, Weiyin Liu, Yuwei Liu   +3 more
openaire   +1 more source

Benchmarking Heterogeneous Electrocatalysts for the Oxygen Evolution Reaction

Journal of the American Chemical Society, 2013
Objective evaluation of the activity of electrocatalysts for water oxidation is of fundamental importance for the development of promising energy conversion technologies including integrated solar water-splitting devices, water electrolyzers, and Li-air batteries.
McCrory, Charles C. L., Jung, Suho, Peters, Jonas C., Jaramillo, Thomas F.   +3 more
openaire   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Operando Acoustic Spectroscopy for Optimizing Gas Evolution In Hydrogen Evolution Reaction and the Oxygen Evolution Reaction Processes

ChemElectroChem
The use of earth‐abundant materials for novel electrodes for solar‐driven electrolysis will play a significant role in the future production of hydrogen as a green energy source.
Christopher Kent, Alex Knowles, Ailbe Ó Manacháin, Colm O’Dwyer, Dara Fitzpatrick   +4 more
doaj   +1 more source