Results 81 to 90 of about 385,675 (250)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Electric-field-assisted proton coupling enhanced oxygen evolution reaction

Nature Communications
The discovery of Mn-Ca complex in photosystem II stimulates research of manganese-based catalysts for oxygen evolution reaction (OER). However, conventional chemical strategies face challenges in regulating the four electron-proton processes of OER ...
Xuelei Pan, Mengyu Yan, Qian Liu, Xunbiao Zhou, Xiaobin Liao, Congli Sun, Jiexin Zhu, Callum McAleese, Pierre Couture, Matthew K. Sharpe, Richard Smith, Nianhua Peng, Jonathan England, Shik Chi Edman Tsang, Yunlong Zhao, Liqiang Mai   +15 more
doaj   +1 more source

Mn3O4@CoMn2O4-CoxOy nanoparticles : partial cation exchange synthesis and electrocatalytic properties toward the oxygen reduction and evolution reactions [PDF]

, 2016
Mn3O4@CoMn2O4 nanoparticles (NPs) were produced at low temperature and ambient atmosphere using a one -pot two-step synthesis protocol involving the cation exchange of Mn by Co in preformed Mn3O4 NPs. Selecting the proper cobalt precursor, the nucleation
Andreu, Teresa, Arbiol, Jordi, Cabot Codina, Andreu, Cadavid, Doris, de la Mata, María, Genç, Aziz, Ibañez, María, Irtem, Erdem, Liu, Yu, Llorca Piqué, Jordi, Luo, Zhishan, Martí Sanchez, Sara, Morante Lleonart, Joan Ramon, Nafria Soler, Raquel   +13 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Electrocatalysts based on metal@carbon core@shell nanocomposites: An overview

Green Energy & Environment, 2018
Developing low-cost, high-performance catalysts is of fundamental significance for electrochemical energy conversion and storage. In recent years, metal@carbon core@shell nanocomposites have emerged as a unique class of functional nanomaterials that show
Yi Peng, Shaowei Chen
doaj   +1 more source

Investigation of the Pt/YSZ interface at low oxygen partial pressure by solid electrochemical mass spectroscopy under high vacuum conditions [PDF]

, 2018
The Pt/YSZ interface was investigated at low oxygen partial pressure under high vacuum (HV) conditions at 400°C. Two different electrochemical techniques were coupled to mass spectrometric gas analysis using a new solid electrochemical mass spectrometric
Comninellis, Christos, Falgairette, Cyril, Foti, György, Harbich, Wolfgang, Li, YongDan, Xia, Chun   +5 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Efficient electrocatalysts derived from praseodymium-doped MOFs and MXene for oxygen reduction, hydrogen evolution, and oxygen evolution reactions

Carbon Trends
In response to the urgent need for high-performance non-precious metal electrocatalysts to address the energy crisis and reduce dependence on fossil fuels, we propose a novel approach to develop a highly selective and efficient electrocatalyst derived ...
Mozhgan Hadavand, Mehdi Mehrpooya, Mohammad Reza Ganjali   +2 more
doaj   +1 more source

The (In)Stability of Heterostructures During the Oxygen Evolution Reaction

Advanced Energy Materials
AbstractThe urgent need for efficient oxygen evolution reaction (OER) catalysts has led to the development and publication of many heterostructured catalysts. The application of such catalysts with multiple phases tremendously increases the material design dimensions, and numerous interface‐related effects can tune the OER performance.
Indranil Mondal, J. Niklas Hausmann, Stefan Mebs, Shweta Kalra, Gonela Vijaykumar, Konstantin Laun, Ingo Zebger, Sören Selve, Holger Dau, Matthias Driess, Prashanth W Menezes   +10 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source