Results 101 to 110 of about 385,675 (250)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Different electrode modification protocols for evaluating the water-splitting properties of a P(V)-metalloporphyrin [PDF]

open access: yesJournal of the Serbian Chemical Society
Water electrolysis is currently a notable research domain, having the identification of highly active, stable, and low-cost electrocatalysts as one of its most important pursuits.
Taranu Bogdan-Ovidiu
doaj   +1 more source

Application of Oxygen Reduction Reaction, Oxygen Evolution Reaction and Hydrogen Evolution Reaction in Electrochemical Biosensing

open access: yesInternational Journal of Electrochemical Science, 2022
Jianlin Zhou   +3 more
openaire   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

The Effects of Changes in Reaction Rates on Simulations of Nova Explosions

open access: yes, 2007
Classical novae participate in the cycle of Galactic chemical evolution in which grains and metal enriched gas in their ejecta, supplementing those of supernovae, AGB stars, and Wolf-Rayet stars, are a source of heavy elements for the ISM.
Hix, W. R.   +4 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Three reversible states controlled on a gold monoatomic contact by the electrochemical potential

open access: yes, 2008
Conductance of an Au mono atomic contact was investigated under the electrochemical potential control. The Au contact showed three different behaviors depending on the potential: 1 $G_{0}$ ($G_{0}$ = $2e^{2}/h$), 0.5 $G_{0}$ and not-well defined values ...
A. Zangwill   +6 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Operando Acoustic Spectroscopy for Optimizing Gas Evolution In Hydrogen Evolution Reaction and the Oxygen Evolution Reaction Processes

open access: yesChemElectroChem
The use of earth‐abundant materials for novel electrodes for solar‐driven electrolysis will play a significant role in the future production of hydrogen as a green energy source.
Christopher Kent   +4 more
doaj   +1 more source

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