Results 171 to 180 of about 57,040 (314)

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView., 2023
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius   +2 more
wiley   +1 more source

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens   +3 more
wiley   +1 more source

Hydrogen: an advanced and safest gas option for cancer treatment. [PDF]

open access: yesMed Gas Res
Gupta N   +4 more
europepmc   +1 more source

Inhibition of Lactate Accumulation via USP38‐Mediated MCT1 Deubiquitination Activates AKT/mTOR Signaling to Mitigate PM2.5‐Induced Lung Injury

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
PM2.5 modulates the metabolic pathways of pulmonary epithelial cells, reprogramming their metabolic profile to favor glycolysis and consequently leading to an increase in lactate production. Excess lactate induces apoptosis by inhibiting the AKT/mTOR pathway, offering a novel metabolic perspective on PM2.5‐induced lung injury.
Zixiao Chen   +8 more
wiley   +1 more source

Long-term outcomes in five patients with autoimmune pulmonary alveolar proteinosis treated with molgramostim inhalation solution. [PDF]

open access: yesERJ Open Res
Montaño C   +7 more
europepmc   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy