Results 41 to 50 of about 57,040 (314)

ORRN: An ODE-based Recursive Registration Network for Deformable Respiratory Motion Estimation with Lung 4DCT Images [PDF]

arXiv, 2023
Deformable Image Registration (DIR) plays a significant role in quantifying deformation in medical data. Recent Deep Learning methods have shown promising accuracy and speedup for registering a pair of medical images. However, in 4D (3D + time) medical data, organ motion, such as respiratory motion and heart beating, can not be effectively modeled by ...
arxiv  

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Reinforcement Learning Assisted Oxygen Therapy for COVID-19 Patients Under Intensive Care [PDF]

arXiv, 2021
Patients with severe Coronavirus disease 19 (COVID-19) typically require supplemental oxygen as an essential treatment. We developed a machine learning algorithm, based on a deep Reinforcement Learning (RL), for continuous management of oxygen flow rate for critical ill patients under intensive care, which can identify the optimal personalized oxygen ...
arxiv  

Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
This study introduces a novel HCC treatment using poly lactic‐co‐glycolic acid (PLGA) nanoparticles encased in HCC cell membranes to co‐deliver Lenvatinib and FePt nanoparticles. This approach improves treatment efficacy by enhancing ferroptosis and apoptosis.
Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang   +11 more
wiley   +1 more source

ICONIC study—conservative versus conventional oxygenation targets in intensive care patients: study protocol for a randomized clinical trial

Trials, 2022
Background Oxygen therapy is a widely used intervention in acutely ill patients in the intensive care unit (ICU). It is established that not only hypoxia, but also prolonged hyperoxia is associated with poor patient-centered outcomes.
C. C. A. Grim, L. I. van der Wal, H. J. F. Helmerhorst, D. J. van Westerloo, P. Pelosi, M. J. Schultz, E. de Jonge, for the ICONIC Investigators and PROVE Network   +7 more
doaj   +1 more source

Wireless Earphone-based Real-Time Monitoring of Breathing Exercises: A Deep Learning Approach [PDF]

in IEEE International Conference on Engineering in Medicine and Biology Society, 2024, pp. 1-4
Several therapy routines require deep breathing exercises as a key component and patients undergoing such therapies must perform these exercises regularly. Assessing the outcome of a therapy and tailoring its course necessitates monitoring a patient's compliance with the therapy. While therapy compliance monitoring is routine in a clinical environment,
arxiv   +1 more source

Decline of COPD exacerbations in clinical trials over two decades -- a systematic review and meta-regression [PDF]

Respiratory Research 20:186, 2019, 2019
BACKGROUND: An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials.
arxiv   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA

Cancer Communications, Volume 42, Issue 12, Page 1347-1366, December 2022., 2022
Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and translation efficiency. However, its role in cancer development and prognosis has not yet been explored.
Xiao Zheng, Qi Wang, You Zhou, Dachuan Zhang, Yiting Geng, Wenwei Hu, Changping Wu, Yufang Shi, Jingting Jiang   +8 more
wiley   +1 more source

Case report: thermal helium in the treatment of coronavirus pneumonia caused by new coronavirus infection COVID-19 (SARS-CoV-2)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
The novel SARS-CoV-2 coronavirus, which originated in December 2019 in Wuhan, China, has triggered an outbreak of a respiratory illness called COVID-19. Helium is a colorless inert gas, odorless and tasteless.
S. V. Zhuravel’, P. V. Gavrilov, N. K. Kuznetsova, I. I. Utkina, M. A. Talyzin, V. E. Aleksandrova   +5 more
doaj   +1 more source