Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
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Mechanism of methylphosphonic acid photo-degradation based on phosphate oxygen isotopes and density functional theory. [PDF]
Xia C +9 more
europepmc +1 more source
Tackling cancer stemness with nanotechnology in the era of precision medicine
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
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Flows of people in villages and large centres in Bronze Age Italy through strontium and oxygen isotopes. [PDF]
Cavazzuti C +7 more
europepmc +1 more source
Diet of bird‐like troodontid dinosaurs: synthesis of a contentious clade
ABSTRACT Troodontidae is a clade of small‐to medium‐sized maniraptoran theropods that mainly lived in Laurasia (modern Asia, North America and Europe) during the Jurassic and Cretaceous periods and are believed to have had a variety of diets. The uniqueness of troodontid teeth suggests that they diverged from the typical flesh‐based diet of non‐avian ...
Yui Chi Fan +2 more
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We proposed a new “hydrogen transfer–desorption” synergistic regulation strategy and developed a Ru/Al2O3‐La‐C catalyst with dual functions. La‐O sites were constructed and carbon components were introduced into the catalyst to regulate the two key steps of hydrogen transfer and desorption on the catalyst surface, respectively, solving the problem of ...
Xiang Li +3 more
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Tooth oxygen isotopes reveal Late Bronze Age origin of Mediterranean fish aquaculture and trade. [PDF]
Guy SV +7 more
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Interfacial Ru–O–W Orbital Coupling Enables Lattice Oxygen Stabilization for Enhanced Acidic OER
A RuO2/WO3 electrocatalyst with strong interfacial Ru–O–W bonds exhibits optimized Ru–O interactions, enhancing intrinsic activity and stability for acidic OER. The WO3 support modulates the electronic structure of RuO2 and promotes oxo‐intermediate deprotonation, delivering a low overpotential of 203 mV at 10 mA cm−2 and sustained operation beyond 200
Tongzhou Wang +9 more
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Functionalizing Conductive Diamond: Recent Advance in Fabrication, Modifications, and Applications
This review highlights recent advancements in the synthesis, modification, and electrochemical applications of conductive diamond, particularly boron‐doped diamond (BDD). It emphasizes progress in fabrication methods, including CVD and HPHT, and explores modifications such as doping, surface terminations, and composite design, enabling significant ...
Ning Linghu, Xin Jiang, Jing Xu
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