Results 71 to 80 of about 1,098,304 (355)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Transient study of the oxygen reduction reaction on reduced Pt and Pt alloys microelectrodes: evidence for the reduction of pre-adsorbed oxygen species linked to dissolved oxygen

, 2015
Using chronoamperometry at preconditioned oxide-free Pt microdisc electrodes in aqueous media, we investigated the oxygen reduction reaction (ORR) on the millisecond timescale and obtained results consistent with the reduction of oxygen species which ...
Denuault, Guy, Perry, Samuel
core   +1 more source

Catalysis of oxygen reduction in PEM fuel cell by seawater biofilm [PDF]

, 2005
The catalysis of oxygen reduction on metallic materials has been widely studied in the domain of aerobic corrosion. In this framework, it has been stated that seawater biofilms are able to catalyse efficiently oxygen reduction on stainless steels.
Bergel, Alain, Féron, Damien, Mollica, Alfonso   +2 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transition Metal-Based Polyoxometalates for Oxygen Electrode Bifunctional Electrocatalysis

Batteries
Polyoxometalates (POMs) with transition metals (Co, Cu, Fe, Mn, Ni) of Keggin structure and lamellar-stacked multi-layer morphology were synthesized. They were subsequently explored as bifunctional electrocatalysts for oxygen electrodes, i.e., oxygen ...
Jadranka Milikić, Filipe Gusmão, Sara Knežević, Nemanja Gavrilov, Anup Paul, Diogo M. F. Santos, Biljana Šljukić   +6 more
doaj   +1 more source

Pt Submonolayer Decorated PdAu/C Nanocatalyst for Oxygen Reduction Reaction

International Journal of Electrochemical Science, 2018
We measured the activity of nanocatalyst, comprising Pt submonolayer decorated PdAu/C substrate (doneted as Pt-PdAu/C) with Pd/Au atomic ratio 4/1, in the oxygen reduction reaction in acidic media.
Weiping Li, Zhilu Le, Tianxiang Zhou, Mengyin Liao, Hesheng Liu, Bing Na, Yijun Yu, Bin Wang, Haiying Zhou, Zhiliang Liao, Keyi Zhang   +10 more
doaj   +1 more source

Effects of heat treatment on the catalytic activity and methanol tolerance of carbon-supported platinum alloys [PDF]

, 2012
This work studies the effect of heat treatment of carbon-dispersed platinum and platinum alloys on its methanol tolerance and catalytic activity as gas diffusion electrodes for oxygen reduction reaction (ORR) in acid medium.
C Lamy, CJ Tseng, CWB Bezerra, H Yang, H Yang, HA Gasteiger, JRC Salgado, KL Hsueh, L Xiong, L Xiong, LGRA Santos, M Neergat, S Mukerjee, T Maiyalagan, V Baglio, V Baglio, V Baglio, WZ Li, X Zhao, Y Bing   +19 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mass-transport resistances of acid and alkaline ionomer layers: A microelectrode study part 1 - Microelectrode development [PDF]

, 2019
The use of microelectrodes to study localized mass-transport phenomena in fuel-cell catalyst layers is an increasingly valuable tool. However, existing microelectrode cells have been used in static, equilibrated environment modes with poorly controlled ...
Danilovic, N, Kushner, DI, Petrovick, JG, Radke, CJ, Tesfaye, M, Weber, AZ   +5 more
core