Results 41 to 50 of about 654,216 (265)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Commentary: Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

Frontiers in Medicine, 2023
Salvatore Chirumbolo, Marianno Franzini, Sergio Pandolfi, Umberto Tirelli, Luigi Valdenassi   +4 more
doaj   +1 more source

Efficacy of Hyperbaric Oxygen Therapy for Radiation Cystitis—A Local Center Experience

Hong Kong Journal of Emergency Medicine
Introduction Radiation cystitis is a debilitating condition with no standardized management protocol, significantly impairing the quality of life of patients with cancer treated with pelvic radiotherapy. Hyperbaric oxygen therapy (HBOT) is recognized for
W. C. Yu, A. Siu, W. W. Yan, K. B. Tang
doaj   +1 more source

Oxygen therapy

Journal of Pediatric Critical Care, 2018
Oxygen is life and falls in the category of essential drug. It is vital for cellular function. Oxygen therapy is the administration of oxygen in acute or chronic conditions above higher concentration than atmospheric air to prevent hypoxemia.
Kundan Mittal, Amit Jain, Teena Bansal, Prashant Kumar, Anupama Mittal   +4 more
doaj   +1 more source

Oxygen Therapy and Toxicity

Veterinary Clinics of North America: Small Animal Practice, 2002
Oxygen (O2) supplementation increases the O2 content of blood, increases the partial pressure of oxygen (PO2) in the capillary blood, and improves tissue delivery of O2. In addition to improving tissue oxygenation, the administration of O2 may improve the function of O2-dependent cellular systems, such as the cytochrome P450 system, which is important ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predicting Training Transfer of Oxygen Therapy During COVID-19: Theory of Planned Behavior Application [PDF]

Journal of Holistic Nursing and Midwifery, 2023
Introduction: Patients with severe COVID-19 symptoms need respiratory support. Therefore, nurses should use oxygen therapy knowledge and skills to treat such patients.
Hatam Faraji Dehsorkhi, Mostafa Azizi Shamami, Ali Asghar Hayat, Javad Rokni   +3 more
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Case report: Consecutive hyperbaric oxygen therapy for delayed post-hypoxic leukoencephalopathy resulting from CHANTER syndrome caused by opioid intoxication

Frontiers in Medicine
Delayed post-hypoxic leukoencephalopathy (DPHL) is a poorly recognized syndrome characterized by neuropsychiatric symptoms following recovery from an acute hypoxic episode.
Naoto Jingami, Naoto Jingami, Naoto Jingami, Kosai Cho, Takayuki Nitta, Miwa Takatani, Katsuya Kobayashi, Ryo Takenaka, Naoko Sugita, Shigeru Ohtsuru, Shigeru Ohtsuru   +10 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source