Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Role of Intensive Insulin Therapy on Superoxide Dismutase (Sod), Tumor Necrosis Factor-? (Tnf-?), and Interleukin-6 (Il-6) on Hyperglycemia in Critically Ill Patients [PDF]
, 2009 Hyperglycemia and insulin resistance are common in critically ill patientsin the ICU, although they have not previously had diabetes. It has been reportedthat pronounced hyperglycemia may lead to complications in such patients, andcause the reactive ...
Bagianto, H. (Hari) +3 more
core +2 more sources
Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome. [PDF]
, 2011 A study published in the previous issue of Critical Care demonstrates that measurement of the pulmonary dead-space fraction is superior to hypoxemia as an indicator of a favorable physiologic response to prone positioning in patients with severe acute ...
Kallet, Richard H, Matthay, Michael A
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Efficacy of Hyperbaric Oxygen Therapy for Radiation Cystitis—A Local Center Experience
Hong Kong Journal of Emergency MedicineIntroduction Radiation cystitis is a debilitating condition with no standardized management protocol, significantly impairing the quality of life of patients with cancer treated with pelvic radiotherapy. Hyperbaric oxygen therapy (HBOT) is recognized for
W. C. Yu, A. Siu, W. W. Yan, K. B. Tang
doaj +1 more source
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers
Journal of Diabetes Research, 2013 Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ...
Figen Aydin +7 more
doaj +1 more source
Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency [PDF]
, 2017 Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by
Atkin, S. L. +11 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in MedicineDelayed post-hypoxic leukoencephalopathy (DPHL) is a poorly recognized syndrome characterized by neuropsychiatric symptoms following recovery from an acute hypoxic episode.
Naoto Jingami +10 more
doaj +1 more source