Results 101 to 110 of about 60,708 (241)

Kurarinone alleviates hemin‐induced neuroinflammation and microglia‐mediated neurotoxicity by shifting microglial M1/M2 polarization via regulating the IGF1/PI3K/Akt signaling

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1213-1223, December 2022., 2022
Abstract Cerebral hemorrhage is a fatal disease that causes severe damage to local nerve function. The purpose of this research is to analyze the effect of kurarinone on hemin‐induced neuroinflammation and neurotoxicity. In our study, according to the results of bioinformatics analysis, we hypothesized that kurarinone might modulate cerebral hemorrhage
Zeng‐Qiang Jia, Cheng Zuo, Wen‐Feng Yue   +2 more
wiley   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

Heme oxygenase 1 is required for mammalian iron reutilization.

Proceedings of the National Academy of Sciences of the United States of America, 1997
The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to
K. Poss, S. Tonegawa
semanticscholar   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

From minute to day: Ecophysiological response of phytoplankton to fluctuating light exposure during vertical mixing

Limnology and Oceanography, Volume 67, Issue 12, Page 2809-2820, December 2022., 2022
Abstract Underwater light is a highly dynamic resource for phytoplankton. Fluctuating light influences photosynthesis, respiration, biosynthesis, and growth at different timescales, but the interplay of these processes is not well‐understood. Subsamples of a phytoplankton community from the turbid, well‐mixed lake TaiHu (China) were either vertically ...
Alexis Lucas Norbert Guislain, Jan Köhler   +1 more
wiley   +1 more source

Heme oxygenase-1: a metabolic nike.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. RECENT ADVANCES The heme oxygenases (HO) are metabolic enzymes that
B. Wegiel, Zsuzsanna Nemeth, Matheus Correa-Costa, A. Bulmer, L. Otterbein   +4 more
semanticscholar   +1 more source

Exposure Experiments to Test the Kinetic Stability of 5‐hydroxymethylfurfural Oxidase (HMFO) in Different Reactor Environments

ChemCatChem, Accepted Article.
The impact of agitation on protein aggregation is often misattributed to shear stress rather than related phenomena such as cavitation and entrainment. For some time now, it has been known that shear is unlikely to harm most proteins directly. Rather, interfacial phenomena, particularly those involving dynamic gas‐liquid interfaces, are critical ...
Amalie Vang Høst, Moritz Meyer, Patrick Bongartz, Marco W. Fraaije, John M. Woodley   +4 more
wiley   +1 more source

Signaling function of heme oxygenase proteins.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Many reports have underscored the importance of the heme degradation pathway that is regulated by heme oxygenase (HO). This reaction releases bile pigments and carbon monoxide (CO), which are important antioxidant and signaling molecules ...
P. Dennery
semanticscholar   +1 more source

Pioneering Women Shaping the Field of Biocatalysis

ChemCatChem, EarlyView.
Groundbreaking works of women scientists in biocatalysis are highlighted in this article. Their innovative contributions are categorized in four interrelated research areas, collectively driving advancements in enzymatic biotransformations. Abstract In this perspective article, we celebrate the accomplishments of female‐led research groups in ...
Ana I. Benítez‐Mateos, Caroline E. Paul, Sandy Schmidt, Martina Letizia Contente   +3 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source