Results 101 to 110 of about 175,409 (339)

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]

, 2015
Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Petrillo, Sara, Pelosi, Laura, Piemonte, Fiorella, Travaglini, Lorena, Forcina, Laura, Catteruccia, Michela, Petrini, Stefania, Verardo, Margherita, D'Amico, Adele, Musaro', Antonio, Bertini, Enrico   +10 more
core   +3 more sources

Spectroscopic Interrogation of Thiolate Hydrogen Bonding in the CO Sensor Protein CooA: Implications for Thiolate Ligation Stability and Cytochrome P450 Function

Chemistry – A European Journal, EarlyView.
Heme proteins are important biomolecules. Proximal cysteine thiolate ligation is found both in heme enzymes such as cytochromes P450 (CYP) and regulatory proteins such as CooA, a CO sensor. The role of H‐bonding to this cysteine is explored in CooA, including variants, and CYP119 using optical and paramagnetic resonance spectroscopies, which highlight ...
Brian R. Weaver, Richard J. Jodts, Brian M. Hoffman, Joshua Telser, Judith N. Burstyn   +4 more
wiley   +1 more source

Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase [PDF]

, 2000
An Acinetobacter sp. genetic screen was used to probe structure-function relationships in vanillate demethylase, a two-component monooxygenase. Mutants with null, leaky, and heat-sensitive phenotypes were isolated.
Morawski, Birgit, Ornston, L. Nicholas, Segura, Ana   +2 more
core  

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Effects of nanoparticles on murine macrophages [PDF]

, 2010
Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated.
A van Dorsselaer, C Aude-Garcia, C Lelong, D Diallo, H Diemer, Kwon Y M, M Chevallet, S Candéias, S Luche, S Triboulet, T Rabilloud, V Collin-Faure   +11 more
core   +4 more sources

Terpenes and Terpenoids: How can we use them?

European Journal of Organic Chemistry, EarlyView.
The transition from petroleum‐based to renewable bio‐based chemicals has led to increased interest in terpenes and terpenoids. This overview highlights their chemistry, focusing on their reactivity and applications in polymerizations, total syntheses, pharmaceuticals, and bio‐based chemical conversions; promoting sustainable and green chemical ...
Jay Hanssens, Diego Meneses, Jordy M. Saya, Romano V. A. Orru   +3 more
wiley   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

Relationship between NOX4 level and angiotensin II signaling in Gitelman's syndrome. Implications with hypertension [PDF]

, 2015
Recent evidence showed that endogenous nicotinamide adenine dinucleotide phosphate-oxidase 4 (NOX4) may exert a protective role on the cardiovascular system inducing vasodilation, reduction of blood pressure, and anti-proliferative actions.
Calò, Lorenzo A, Davis, Paul A, Maiolino, Giuseppe, Pagnin, Elisa, Ravarotto, Verdiana, Savoia, Carmine   +5 more
core  

The induction of heme oxygenase 1 decreases contractility in human internal thoracic artery and radial artery grafts [PDF]

, 2005
ObjectiveSpasm remains a potential problem encountered during the use of arterial grafts in coronary artery bypass surgery. Heme oxygenase plays a role in the control of arterial vasoreactivity.
Achouh, Paul, Badier-Commander, Cécile, Chardigny, Catherine, Fabiani, Jean-Noël, Khabbaz, Ziad, Simonet, Serge, Vayssettes-Courchay, Christine, Verbeuren, Tony J., Zegdi, Rachid   +8 more
core   +1 more source