Results 101 to 110 of about 220,248 (385)

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.

Journal of Clinical Investigation, 1999
The first known human case of heme oxygenase-1 (HO-1) deficiency is presented in this report. The patient is a six-year-old boy with severe growth retardation.
A. Yachie, Y. Niida, T. Wada, N. Igarashi, H. Kaneda, T. Toma, K. Ohta, Y. Kasahara, S. Koizumi   +8 more
semanticscholar   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Reduced stress defense in heme oxygenase 1-deficient cells.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of Hmox1 in cellular antioxidant defense, we analyzed the responses of cells ...
Kenneth D. Poss, S. Tonegawa
semanticscholar   +1 more source

Antagonistic Ghd7‐OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

Advanced Science, EarlyView.
The complex centered on Ghd7 binds to numerous carbon and nitrogen metabolism genes on the genome through the corresponding motifs and transactivates the transcriptional expression of these carbon and nitrogen metabolism genes. With the assistance of OsNAC42 and other unknown Ghd7‐interacting proteins, this complex can regulate different metabolic ...
Guangming Lou, Pingli Chen, Pingbo Li, Haozhou Gao, Jiawang Xiong, Shanshan Wan, Yuanyuan Zheng, Yufu Wang, Mufid Alam, Yingnanjun Chen, Lei Wang, Jingjing Bai, Xuan Tan, Wenting Rao, Bian Wu, Hao Zhou, Yanhua Li, Guanjun Gao, Qinglu Zhang, Jinghua Xiao, Xianghua Li, Xuelei lai, Qifa Zhang, Yuqing He   +23 more
wiley   +1 more source

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

Neural Regeneration Research
Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive ...
Qi Gu, Weiping Sha, Qun Huang, Jin Wang, Yi Zhu, Tianli Xu, Zhenhua Xu, Qiancheng Zhu, Jianfei Ge, Shoujin Tian, Xiaolong Lin   +10 more
doaj   +1 more source

Differential Expression of the Demosponge (Suberites domuncula) Carotenoid Oxygenases in Response to Light: Protection Mechanism Against the Self-Produced Toxic Protein (Suberitine)

Marine Drugs, 2012
The demosponge Suberites domuncula has been described to contain high levels of a proteinaceous toxin, Suberitine, that displays haemolytic activityIn the present study this 7–8 kDa polypeptide has been isolated and was shown to exhibit also cytotoxic ...
Heinz C. Schröder, Matthias Wiens, Werner E. G. Müller, Xiaohong Wang, Michael Binder, Johannes von Lintig   +5 more
doaj   +1 more source

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression [PDF]

, 2010
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases ...
A Babusyte, A Kode, A Papi, A Sebastian, A Sydbom, AP Rogerio, AW Boots, C Kandaswami, C Tabak, CJ Vlahos, D Nowak, DC Newcomb, EH Walker, G Agullo, GA Finlay, GW Peet, HJ Park, HS Deshmukh, HS Deshmukh, I Rahman, IC Walda, IK Demedts, J Robak, JA Conquer, JC Chen, JD Hasday, JH Vernooy, JW Hwang, K Ito, K Minamoto, K Ohnishi, KF Chung, KK Meja, L Biasutto, L Larsson, L Segura-Valdez, M Comalada, M Harwood, M Ichinose, M Kasielski, M Suzuki, MK Hwang, MM Mu, N Louhelainen, O Michel, P Maestrelli, P Santus, PC Hollman, PF Mercer, PJ Jagielo, R Mahadeva, S Nanua, S Rajendrasozhan, S Shishodia, SK Biswas, SP Davies, SV Culpitt, T Shinohara, T Zheng, U Sajjan, W MacNee, Y Kaneko, Y Nakamaru, Y-T Huang   +63 more
core   +6 more sources

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

Advanced Science, EarlyView.
This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang, Faying Chen, Bao‐Dan He, Fan‐Chen Wang, Jiaxue Cha, Yu Song, Wei‐Ying Meng, Wan‐Yue Zou, Yu‐Tao Fu, Shu‐Xia Sun, Zhi‐Yan Sun, Hao‐Ming Jiang, Ke‐Yao Zhao, Yujun Hou, Jiejun Shi, Jian‐Huang Xue   +15 more
wiley   +1 more source

Human Mesenchymal Stem Cells Elevate CD4+CD25+CD127low/- Regulatory T Cells of Asthmatic Patients via Heme Oxygenase-1

Iranian Journal of Allergy, Asthma and Immunology, 2013
Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro,  meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li, Yong-xun Zhuan-sun, Bing Wen, Hao Wu, Feng-ting Huang, Hridaya bibhu Ghimire, Pi-xin Ran   +6 more
doaj  

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source