Results 111 to 120 of about 175,409 (339)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Cytokine Expression of Microscopic Colitis Including Interleukin-17

Gut and Liver, 2015
Background/AimsMicroscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination.
doaj   +1 more source

Three novel science activities relating to the structure of the atom, bioinformatics, and the denaturation of protein [PDF]

, 2013
Plan B Paper. 2013. Master of Science in Education- Physics--University of Wisconsin-River Falls. Physics Department. 30 leaves. Includes bibliographical references (leaf 10).This paper describes three novel activities that were designed to teach ...
Duerst, Robert
core   +1 more source

Oxygen Activation by the Iron(II)-2-Mercaptobenzoic Acid Complex. A Model for Microsomal Mixed Function Oxygenases [PDF]

, 1969
Volker Ullrich
openalex   +1 more source

Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy

Exploration, EarlyView.
Self‐assembled S‐Cu(I)‐S sites were spatially isolated onto a two‐dimensional Ti3C2 surface to produce a structurally well‐defined and highly functional single‐site copper(I) nanomodulator CuNTD, which can induce severe immunogenic cell death through multiple regulatory pathways of synergistic cascade photothermal‐amplified ROS storms, cuproptosis and ...
Yuanyuan Zhang, Shengnan Ya, Jingnan Huang, Yangyang Ju, Xueyang Fang, Xinteng Ouyang, Qingdong Zeng, Xinyao Zhou, Xiyun Yan, Guohui Nie, Kelong Fan, Bin Zhang   +11 more
wiley   +1 more source

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. [PDF]

, 1968
R Tenhunen, Harvey S. Marver, R. Schmid
openalex   +1 more source

Heme Oxygenase-1 Deficiency [PDF]

Indian Pediatrics, 2021
Manisha Madkaikar, Soumya Renji, Nitin Shah   +2 more
openaire   +5 more sources

Alfalfa Flavonoids Mitigate Salmonella‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways

Food Frontiers, EarlyView.
Alfalfa flavonoids (AF) protected against Salmonella‐induced colitis by reducing inflammation and oxidative stress. AF inhibited the TLR4/IκB/NF‐κB/COX‐2 pathway and NLRP3 inflammasome, lowering pro‐inflammatory cytokines, while activating Keap1‐Nrf2 to boost antioxidants (e.g., HO‐1, NQO1, SOD, GPx), decreasing ROS‐driven oxidative stress.
Xiaoli Qin, Yan Lu, Yawen Luo, Yafang Cui, Kai Zhao, Yang He, Muhammad Aziz ur Rahman, Shengnan Min, Wenfang Wang, Fuyu Yang, Binghai Cao, Huawei Su   +11 more
wiley   +1 more source

A Protochlorophyllide (Pchlide) a Oxygenase for Plant Viability

Frontiers in Plant Science, 2019
Higher plants contain a small, 5-member family of Rieske non-heme oxygenases that comprise the inner plastid envelope protein TIC55, phaeophorbide a oxygenasee (PAO), chlorophyllide a oxygenase (CAO), choline monooxygenase, and a 52 kDa protein (PTC52 ...
Steffen Reinbothe, Sandra Bartsch, Claudia Rossig, Manli Yang Davis, Shu Yuan, Christiane Reinbothe, John Gray   +6 more
doaj   +1 more source