Results 351 to 360 of about 220,248 (385)

The mechanism of heme oxygenase

Current Opinion in Chemical Biology, 2000
Major advances have been made in determining the structure of heme oxygenase and the relationship between its structure and catalytic activity. The nature of the first step in the reaction sequence, heme alpha-meso-hydroxylation, is now clear, although the mechanisms that control the alpha-regiospecificity remain elusive. Hypothetical mechanisms can be
openaire   +3 more sources

Analgesia and cyclo-oxygenase inhibitors

Digestive and Liver Disease, 2001
Non-steroidal anti-inflammatory drugs are among the most commonly used medications and they are a mainstay in the treatment of inflammatory diseases. Non-steroidal anti-inflammatory drugs are widely used to reduce pain associated with acute or chronic inflammation.
MELI, ROSARIA, Antonelli E, CIRINO, GIUSEPPE   +2 more
openaire   +4 more sources

Oxidases and Oxygenases

2007
An oxidase catalyzes the oxidation of a substrate by O2 without incorporating an oxygen atom into the product. A monooxygenase catalyzes oxidation by O2 with incorporation of one oxygen atom into the product, and oxidation by a dioxygenase proceeds with incorporation of both atoms of O2 into the product.
Perry A. Frey, Adrian D. Hegeman
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Regulation of inflammation by the antioxidant haem oxygenase 1

Nature reviews. Immunology, 2021
Nicole K. Campbell, Hannah K. Fitzgerald, A. Dunne   +2 more
semanticscholar   +1 more source

The oxygenase Jmjd6--a case study in conflicting assignments.

Biochemical Journal, 2015
The Jumonji domain-containing protein 6 (Jmjd6) is a member of the superfamily of non-haem iron(II) and 2-oxoglutarate (2OG)-dependent oxygenases; it plays an important developmental role in higher animals.
A. Böttger, Md. Saiful Islam, R. Chowdhury, C. Schofield, Alexander Wolf   +4 more
semanticscholar   +1 more source

Cofactor-independent oxidases and oxygenases

Applied Microbiology and Biotechnology, 2010
Whereas the majority of O(2)-metabolizing enzymes depend on transition metal ions or organic cofactors for catalysis, a significant number of oxygenases and oxidases neither contain nor require any cofactor. Among the cofactor-independent oxidases, urate oxidase, coproporphyrinogen oxidase, and formylglycine-generating enzyme are of mechanistic as well
Fetzner S., Steiner R.
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Heme oxygenase-1 as a target for drug discovery.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Heme oxygenase enzymes, which exist as constitutive (HO-2) and inducible (HO-1) isoforms, degrade heme to carbon monoxide (CO) and the bile pigment biliverdin.
R. Motterlini, R. Foresti
semanticscholar   +1 more source

Practical issues in the application of oxygenases

Trends in Biotechnology, 2003
Oxygenases carry out the regio-, stereo- and chemoselective introduction of oxygen in a tremendous range of organic molecules. This versatility has already been exploited in several commercial processes. There are, however, many hurdles to further practical large-scale applications.
Wouter A. Duetz, Jan B. van Beilen, Andreas Schmid, Bernard Witholt   +3 more
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Oxidoreductases and Oxygenases

1984
Oxidoreductases (dehydrogenases or oxidases) catalyze the addition or the removal of hydrogen or electrons. Oxygenases bring about the incorporation of oxygen which originates from molecular oxygen.
openaire   +2 more sources

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

American Journal of Respiratory Cell and Molecular Biology, 1996
Accumulating evidence suggests that oxidative stress plays a central role in the pathogenesis of many pulmonary diseases including adult respiratory distress syndrome, emphysema, asthma, bronchopulmonary dysplasia, and interstitial pulmonary fibrosis ...
Augustine M. K. Choi, Jawed Alam
semanticscholar   +1 more source