Results 71 to 80 of about 175,409 (339)

Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions

Brazilian Journal of Medical and Biological Research, 1999
Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally arises from heme degradation in a
R.A. Johnson, F. Kozma, E. Colombari
doaj   +1 more source

Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons [PDF]

Biochemistry (American Chemical Society) 45 (2006) 12380-12391, 2009
In Sphingomonas CHY-1, a single ring-hydroxylating dioxygenase is responsible for the initial attack of a range of polycyclic aromatic hydrocarbons (PAHs) composed of up to five rings. The components of this enzyme were separately purified and characterized. The oxygenase component (ht-PhnI) was shown to contain one Rieske-type [2Fe-2S] cluster and one
arxiv  

Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide [PDF]

, 2011
Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling.
A. Caillon, B. Toutain, D. Henrion, D. Lambert, L. Loufrani, M.L. Freidja, V. Desquiret-Dumas, V. Procaccio   +7 more
core   +3 more sources

HEME OXYGENASE: ENZYME WITH FUNCTIONAL DIVERSITY [PDF]

Journal of Stress Physiology & Biochemistry, 2011
In recent years role of Heme oxygenase (HO) has been considered in nearly all living system including plants, animals and other organisms. The common role of heme oxygenase is the degradation of heme, although there is a diversity of additional role of ...
Shekhawat G. S., Dixit S., Verma K., Nasybullina E.I., Kosmachevskaya O.V., Topunov A.F.   +5 more
doaj  

Characterization of an efficient N-oxygenase from Saccharothrix sp. and its application in the synthesis of azomycin

Biotechnology for Biofuels and Bioproducts, 2023
Background The nitro group constitutes a significant functional moiety within numerous valuable substances, such as nitroimidazoles, a class of antimicrobial drugs exhibiting broad spectrum activity.
Chuanle Fan, Fang Zhou, Wei Huang, Yi Xue, Chao Xu, Rubing Zhang, Mo Xian, Xinjun Feng   +7 more
doaj   +1 more source

Derivation of the formyl-group oxygen of chlorophyll b from molecular oxygen in greening leaves of a higher plant (Zea mays) [PDF]

, 1993
Using mass spectroscopy, we demonstrate as much as 93% enrichment of the 7-formyl group oxygen of chlorophyll b when dark-grown, etiolated maize leaves are greened under white light in the presence of 18O2. This suggests that a mono-oxygenase is involved
Beale, Björkman, Chunaev, E. Cmiel, H. Scheer, Hennigsen, Ingrid Katheder, Klein, Nashrulhaq-Boyce, Naylor, Porra, R.J. Porra, Rüdiger, Sato, Schneegurt, W. Schäfer, Walker   +16 more
core   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Angewandte Chemie International Edition, EarlyView.
Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

Neural Regeneration Research
Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive ...
Qi Gu, Weiping Sha, Qun Huang, Jin Wang, Yi Zhu, Tianli Xu, Zhenhua Xu, Qiancheng Zhu, Jianfei Ge, Shoujin Tian, Xiaolong Lin   +10 more
doaj   +1 more source

Design principles for site-selective hydroxylation by a Rieske oxygenase

Nature Communications, 2022
SxtT and GxtA are Rieske oxygenases that are involved in paralytic shellfish toxin biosynthesis and catalyze monohydroxylation reactions at different positions on the toxin scaffold.
Jianxin Liu, Jiayi Tian, Christopher Perry, April L. Lukowski, Tzanko I. Doukov, Alison R. H. Narayan, Jennifer Bridwell-Rabb   +6 more
doaj   +1 more source

Differential Expression of the Demosponge (Suberites domuncula) Carotenoid Oxygenases in Response to Light: Protection Mechanism Against the Self-Produced Toxic Protein (Suberitine)

Marine Drugs, 2012
The demosponge Suberites domuncula has been described to contain high levels of a proteinaceous toxin, Suberitine, that displays haemolytic activityIn the present study this 7–8 kDa polypeptide has been isolated and was shown to exhibit also cytotoxic ...
Heinz C. Schröder, Matthias Wiens, Werner E. G. Müller, Xiaohong Wang, Michael Binder, Johannes von Lintig   +5 more
doaj   +1 more source