Results 71 to 80 of about 60,708 (241)

Design principles for site-selective hydroxylation by a Rieske oxygenase

Nature Communications, 2022
SxtT and GxtA are Rieske oxygenases that are involved in paralytic shellfish toxin biosynthesis and catalyze monohydroxylation reactions at different positions on the toxin scaffold.
Jianxin Liu, Jiayi Tian, Christopher Perry, April L. Lukowski, Tzanko I. Doukov, Alison R. H. Narayan, Jennifer Bridwell-Rabb   +6 more
doaj   +1 more source

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

Proceedings of the National Academy of Sciences of the United States of America, 2014
Significance Metabolism of l-carnitine, a compound abundant in human diet, to trimethylamine by human microbiota has been shown to promote atherosclerosis and subsequent development of heart disease.
Yijun Zhu, E. Jameson, M. Crosatti, H. Schäfer, K. Rajakumar, T. Bugg, Yin Chen   +6 more
semanticscholar   +1 more source

Pyrus ussuriensis Maxim 70% ethanol eluted fraction ameliorates inflammation and oxidative stress in LPS‐induced inflammation in vitro and in vivo

Food Science &Nutrition, Volume 11, Issue 1, Page 458-469, January 2023., 2023
In this work, we demonstrated that PUM70 specifically suppressed LPS‐mediated inflammatory responses. Notably, PUM70 treatment inhibited LPS‐induced lung damage, pro‐inflammatory cytokine production, and reduced macrophage infiltration in the lungs. Mechanistically, PUM70 suppressed LPS‐induced inflammation and oxidative stress via the Nrf2/HO‐1 and ...
Fei Peng, Xin Ren, Bin Du, Yuedong Yang
wiley   +1 more source

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

Neural Regeneration Research
Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive ...
Qi Gu, Weiping Sha, Qun Huang, Jin Wang, Yi Zhu, Tianli Xu, Zhenhua Xu, Qiancheng Zhu, Jianfei Ge, Shoujin Tian, Xiaolong Lin   +10 more
doaj   +1 more source

Differential Expression of the Demosponge (Suberites domuncula) Carotenoid Oxygenases in Response to Light: Protection Mechanism Against the Self-Produced Toxic Protein (Suberitine)

Marine Drugs, 2012
The demosponge Suberites domuncula has been described to contain high levels of a proteinaceous toxin, Suberitine, that displays haemolytic activityIn the present study this 7–8 kDa polypeptide has been isolated and was shown to exhibit also cytotoxic ...
Heinz C. Schröder, Matthias Wiens, Werner E. G. Müller, Xiaohong Wang, Michael Binder, Johannes von Lintig   +5 more
doaj   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Angewandte Chemie International Edition, Accepted Article.
Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically and ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering.
Martin Baunach, Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami   +6 more
wiley   +1 more source

Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain

Glia, Volume 71, Issue 2, Page 377-390, February 2023., 2023
Main Points Aging‐related morphological changes in microglia (dystrophy) do not correlate with expression of universal senescence markers. Microglial dystrophy coincides with an aging‐related increase in microglial ferritin expression. Abstract Aging can cause morphological transformation in human microglia indicative of cell senescence, termed ...
Pauline Neumann, Dana E. Lenz, Wolfgang J. Streit, Ingo Bechmann   +3 more
wiley   +1 more source

Human Mesenchymal Stem Cells Elevate CD4+CD25+CD127low/- Regulatory T Cells of Asthmatic Patients via Heme Oxygenase-1

Iranian Journal of Allergy, Asthma and Immunology, 2013
Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro,  meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li, Yong-xun Zhuan-sun, Bing Wen, Hao Wu, Feng-ting Huang, Hridaya bibhu Ghimire, Pi-xin Ran   +6 more
doaj  

Characterization and Function Analysis of the Beta-Carotene Oxygenase-like Genes in Carotenoids Metabolism of the Ridgetail White Prawn Exopalaemon carinicauda

Frontiers in Physiology, 2020
Carotenoids are almost universally distributed in living organisms. The oxidative metabolism by carotene oxygenase contributes to the metabolic processes of carotenoids.
Yue Jin, Yue Jin, Yue Jin, Yang Yu, Yang Yu, Yang Yu, Chengsong Zhang, Chengsong Zhang, Chengsong Zhang, Shihao Li, Shihao Li, Shihao Li, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Fuhua Li, Fuhua Li, Fuhua Li, Fuhua Li   +18 more
doaj   +1 more source

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Bacterial resistance to clinically relevant antibiotics has renewed public interest in identifying therapeutics with new scaffolds for the treatment of such infections. Analogs of orthosomycins could provide one such scaffold.
K. McCulloch, E. K. McCranie, Jarrod A. Smith, M. Sarwar, J. Mathieu, B. L. Gitschlag, Yu Du, B. Bachmann, T. Iverson   +8 more
semanticscholar   +1 more source