Results 81 to 90 of about 60,708 (241)

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Angewandte Chemie International Edition, Accepted Article.
The α‐methylene‐γ‐butyrolactone tulipalin A, a defense compound found in tulips, can polymerize via addition at the vinyl group or via ring‐opening polymerization, making it a highly promising monomer for bio‐based polymers. Since the biosynthesis of tulipalin A in plants remains elusive, we propose an alternative pathway for its synthesis starting ...
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan-Yap, Kamela K. Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells

Biological Research, 2006
Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO, SEBASTIÁN FLORES, FERNANDO PIZARRO, MIGUEL ARREDONDO   +3 more
doaj  

Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease [PDF]

Einstein (São Paulo), 2009
Objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to unilateral ureteral obstruction and divided into groups: non-treated and hemin.
Matheus Corrêa Costa, Patricia Semedo, Ana Paula Fernandes da Silva Monteiro, Rafael Luiz Pereira, Giselle Martins Gonçalves, Marcos Antônio Cenedeze, Ana Carolina Guimarães Faleiros, Marlene Antônia dos Reis, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara   +9 more
doaj  

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Lignin-degrading enzyme from Phanerochaete chrysosporium: Purification, characterization, and catalytic properties of a unique H(2)O(2)-requiring oxygenase.

Proceedings of the National Academy of Sciences of the United States of America, 1984
An extracellular lignin-degrading enzyme from the basidiomycete Phanerochaete chrysosporium Burdsall was purified to homogeneity by ion-exchange chromatography. The 42,000-dalton ligninase contains one protoheme IX per molecule.
M. Tien, T. Kirk
semanticscholar   +1 more source

A Model for the Catabolism of Rhizopine in Rhizobium leguminosarum Involves a Ferredoxin Oxygenase Complex and the Inositol Degradative Pathway

Molecular Plant-Microbe Interactions, 1998
Rhizopines are nodule-specific compounds that confer an intraspecies competitive nodulation advantage to strains that can catabolize them. The rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) catabolic moc gene cluster mocCABRDE(F) in Rhizobium ...
Masoud Bahar, John de Majnik, Margaret Wexler, Judith Fry, Philip S. Poole, Peter J. Murphy   +5 more
doaj   +1 more source

mibPOPdb: An online database for microbial biodegradation of persistent organic pollutants

iMeta, Volume 1, Issue 4, December 2022., 2022
This study presents the Microbial Biodegradation of Persistent Organic Pollutants Database (mibPOPdb) database, a web‐accessible literature‐based microbial biodegradation of persistent organic pollutants (POPs) resource. We also developed a robust chemical biodegradability prediction model with Graph Neural Networks.
Tanyaradzwa R. Ngara, Peiji Zeng, Houjin Zhang   +2 more
wiley   +1 more source

New insights into intracellular locations and functions of heme oxygenase-1.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Heme oxygenase-1 (HMOX1) plays a critical role in the protection of cells, and the inducible enzyme is implicated in a spectrum of human diseases.
L. Dunn, R. G. Midwinter, J. Ni, H. Hamid, C. Parish, R. Stocker   +5 more
semanticscholar   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source