Results 71 to 80 of about 63,041 (289)
Animal Models and Experimental Medicine, EarlyView.Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama +5 more
wiley +1 more source
PLoS ONE, 2011 Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules.
Armin Thalhammer +12 more
doaj +1 more source
Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. [PDF]
PLoS ONE, 2015 Oxidative stress has been known to be involved in pathogenesis of dry eye disease. However, few studies have comprehensively investigated the relationship between hyperosmolarity and oxidative damage in human ocular surface.
Ruzhi Deng +8 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem +6 more
wiley +1 more source
Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases*
Journal of Biological Chemistry, 2015 Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utilize an Fe(IV)-oxo intermediate to initiate diverse oxidative transformations with important biological roles.
S. Martinez, R. Hausinger
semanticscholar +1 more source
Heme Oxygenase and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Overproduction of reactive oxygen species under pathophysiological conditions, including dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of cardiovascular diseases (CVD). The reactive oxygen species released from all types of vascular cells regulate various signaling pathways that mediate not only vascular inflammation
openaire +2 more sources
Journal of the American Chemical Society, 2018 Ten-eleven translocation (TET) enzymes employ O2, earth-abundant iron, and 2-ketoglutarate (2KG) to perform iterative C–H oxidation of 5-methylcytosine in DNA to control expression of the mammalian genome.
Babu Sudhamalla +5 more
semanticscholar +1 more source
Journal of Physical Chemistry A, 2016 Four mechanisms previously proposed for dioxygen activation catalyzed by α-keto acid dependent oxygenases (α-KAO) were studied with dispersion-corrected DFT methods employing B3LYP and TPSSh functionals in combination with triple-ζ basis set (cc-pVTZ ...
A. Wójcik, M. Radoń, T. Borowski
semanticscholar +1 more source
Distribution and diversity of enzymes for polysaccharide degradation in fungi
Scientific Reports, 2017 Fungi are important polysaccharide degraders in the environment and for biotechnology. Here, the increasing number of sequenced fungal genomes allowed for systematic identification of genes and proteins involved in polysaccharide degradation in 218 fungi.
Renaud Berlemont
doaj +1 more source
The non-canonical functions of the heme oxygenases
OncoTarget, 2016 Heme oxygenase (HO) isoforms catalyze the conversion of heme to carbon monoxide (CO) and biliverdin with a concurrent release of iron, which can drive the synthesis of ferritin for iron sequestration.
L. Vanella +5 more
semanticscholar +1 more source